Gastric Adenocarcinoma in Association with Tuberous Sclerosis Case report
Journal Title: Sultan Qaboos University Medical Journal - Year 2009, Vol 9, Issue 1
Abstract
We report the first case of gastric cancer in association with tuberous sclerosis. Tuberous sclerosis is an autosomal dominant disorder which presents with a constellation of signs including benign tumours in the brain and in other vital organs such as the kidneys, heart, eyes, lungs, and skin. A combination of symptoms may include seizures, developmental delay, behavioural problems, skin abnormalities, and lung and kidney disease. It is caused by mutations on either of two genes, tuberous sclerosis genes, TSC or TSC2, which encode for the proteins hamartin and tuberin respectively. Tese proteins act as tumour growth suppressor agents that regulate cell proliferation and differentiation. Tuberous sclerosis has been associated with hamartomatous growths and angiomyolipomas, an association with gastric cancer has not been reported; however, this could be a co-incidental finding and further cases need to be reported.
Authors and Affiliations
Saeed Ahmed| Departments of Medicine, Sultan Qaboos University Hospital, Muscat, Sultanate of Oman, Ikram Burney| Departments of Medicine, Sultan Qaboos University Hospital, Muscat, Sultanate of Oman, Sukhpal Sawhney| Departments of Radiology & Molecular Imaging, Sultan Qaboos University Hospital, Muscat, Sultanate of Oman, Mansour S Al-Moundhri| Department of Medicine, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman
Knowledge and Attitudes Towards Clinical Trial Participation in Oman A cross-sectional study
Objectives: Clinical trials are prospective studies on human subjects designed to answer various clinical questions. However, only a limited number of clinical trials have been conducted in Oman. This study aimed to as...
The ‘5R + R’ Rule: A simple and comprehensive method for diagnosis of actinic keratosis
Dear Editor, Actinic keratoses (AKs) or ‘solar keratoses’ are cutaneous lesions that arise on areas of the skin that are chronically exposed to ultraviolet (UV) radiation [Figure 1]. AKs are considered early manifestat...
Small-Cell Neuroendocrine Carcinoma of the Cervix Masquerading as a Cervical Fibroid Report of a rare entity
Primary neuroendocrine tumours of the cervix are extremely rare, with an incidence of only 0.5–1%; as such, these entities can present a clinical and diagnostic challenge. Small-cell neuroendocrine carcinomas of the ce...
Leiomyoma of the Round Ligament of the Uterus Case report and review of literature
Smooth muscle tumours of the round ligament of the uterus are rare and can mimic an inguinal hernia. Preoperative diagnosis can be established by a computed tomography scan of the abdomen or an exploration of the ingui...
Determination of Heavy Metals in the Common Smokeless Tobacco Afzal in Oman
Objectives: Afzal is an illegally sold smokeless tobacco product (STP) commonly used by youths and teenagers in Oman. Te aim of this study was to analyse the composition of Afzal, also commonly known as sweekah, as it...