Gastrointestinal lesions in patients, administrated acetylsalicylic acid for cardiovascular pathology: the syndromic diagnosis and possible methods of correction
Journal Title: Сучасна гастроентерологія - Year 2018, Vol 0, Issue 1
Abstract
Objective — to determine the effects of acetylsalicylic acid (ASA) preparations on the development of gastrointestinal tract lesions and to assess their severity depending on the use of PPIs, with the help of GSRS questionnaire. Materials and methods. The survey with the use of GSRS questionnaire has been performed on the basis of Vinnitsa Primary Health Care Center №2. It involved 157 patients (84 men and 73 women) with cardiovascular pathology, who received 75 mg of ASA on daily basis. Results. It has been established that occurrence of gastrointestinal disorders directly correlated the duration of ASA administration. It has been proved that dyspeptic syndrome was the leading syndrome in patients, who were taking ASA medications from 6 to 12 months or longer in comparison with those who received ASA for 1 month and from 1 month to 6 months (p < 0.05). There was no such a difference as regards diarrhea, constipation, reflux and abdominal pain syndromes (p > 0.05). Age- and gender-related comparison did not show significant difference (p > 0.05), related to the gastrointestinal disturbances. The simultaneous administration of ASA and PPI resulted in the decrease in the manifestations of dyspepsia syndrome, reflux syndrome and abdominal pain syndrome. Conclusions. The GSRS questionnaire allowed the questioning in outpatient setting for early detection of dyspeptic disorders in patients with cardiovascular disease who receive ASA on daily basis. The long-term ASA administration increased the probability of the development of gastrointestinal disorders, including dyspepsia syndrome (p < 0.05). Age and gender did not affect the terms of dyspeptic disorders onset in patients with cardiovascular diseases, who were taking ASA daily. The simultaneous administration of ASA and PPI resulted in the decrease of dyspeptic manifestations in patients with dyspepsia syndrome, reflux syndrome, and abdominal pain syndrome. The administration of pantoprazole was significantly more effective than omeprazole (p < 0.05).
Authors and Affiliations
I. G. Paliy, S. V. Zaika, A. G. Yankovetska
Keywords
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