Gastrointestinal stromal tumors a clinicopathological study
Journal Title: Journal of the Indian Medical Association - Year 2019, Vol 117, Issue 1
Abstract
Gastrointestinal stromal tumors (GISTs) are the most common primary mesenchymal tumors of the GIT. These develop within the wall of the GIT and occur throughout the GIT from oesophagus to rectum. The KIT mutation results in activation of the tyrosine kinase receptors allowing its detection by immunohistochemistry and helps in confirming the histologic diagnosis of GIST. GISTs are categorized into distinct risk categories and prognostic groups based on tumor size, number of mitoses per 50 high power fields and the anatomic location of the tumor. The present study is of a retrospective, case series nature. Data was retrieved from Pathology archives and Department of Cancer Registry, Malabar Cancer Centre. There were a total of 11 cases in the present study. In our study, almost 20% GISTs occurred below the age of 50 years. Jejunum and iIeum were the commonest sites. Majority of tumors were located in submucosal or intramural locations. All were of spindle cell morphology and CD117 was the most useful antibody, being strong diffuse positive in 70%.
Authors and Affiliations
Sajith K Satheesh, Sangeetha K Nayanar, Basavaraj Ankalkoti
Keywords
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