GASTROPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF DELONIX REGIA FLOWERS IN EXPERIMENTAL INDUCED ULCER IN WISTAR ALBINO RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 5
Abstract
The ethanolic extract of flowers of Delonix regia (leguminosae) was obtained and investigated for its gastro protective activity in experimental induced ulcer model. Pretreatment with 70% ethanolic extract of Delonix regia flowers at the doses (100, 250 and 500mg/kg.p.o) were administered through the oral route. The Antiulcer effect of ethanolic extract of Delonix regia flowers was studied in aspirin, alcohol and pylorus ligation induced gastric ulceration experimental models and the results were compared with that of lansoprazole (8mg/kg, p.o.) as reference standard drug. The various parameters like Ulcer index and percentage protection in all the models and gastric volume, pH of gastric juice, free acidity and total acidity in pylorus ligation induced gastric ulceration model were monitored. From the findings of our study, the ethanolic extract of flowers of Delonix regia showed gastroprotective effect of in a dose dependant manner.
Authors and Affiliations
Rajabhau Shiramane , Basavaraj Chivde , Manoj Kamshetty , Karnakumar Biradar , Asif khan
Keywords
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