Gastroretentive drug delivery systems a potential approach for antihypertensive drugs: An updated review
Journal Title: Asian Pacific Journal of Health Sciences - Year 2018, Vol 5, Issue 2
Abstract
Oral drug delivery system (DDS) is the preferred route of administration of drugs, but poor bioavailability (BA) of orally administered drugs is still a challenging one, though extensive advancements in drug discovery process are made. Drugs with narrow absorption window in the gastrointestinal tract have poor absorption. Gastric emptying of dosage forms is an extremely variable process and ability to prolong and control the emptying time is a valuable asset for dosage forms, which reside in the stomach for a longer period of time than conventional dosage forms. Therefore, gastroretentive DDSs (GRDDSs) have been developed, which prolong the gastric emptying time. Most of the antihypertensive drugs have short half-life, short gastric residence time, low BA, and narrow absorption window. GRDDS can be a viable option for management of hypertension for several antihypertensive drugs. Several techniques such as floating DDS, low-density systems, raft systems, mucoadhesive systems, high-density systems, super porous hydrogels, and magnetic systems have been employed. These forms are expected to remain buoyant on gastric content without affecting the intrinsic rate of emptying. This results in prolonged gastric retention time of floating forms which improve BA of drug and also improve clinical situations. Prolonged gastric retention not only improves the BA and reduces drug waste but also improves solubility for drugs that are less soluble in a high pH environment. It has applications also for local drug delivery to the stomach and proximal small intestines. Gastroretention helps to provide better availability of new products with new therapeutic possibilities and substantial benefits for patients. Hence, it can be concluded that GRDDS promises to be a potential approach for antihypertensive drugs. This review mainly focuses on the different types of GRDDS used for management of hypertension and also includes the updated compiled study of different antihypertensive drugs explored as GR dosage forms.
Authors and Affiliations
Himmat Singh Chawra
Keywords
Related Articles
- EP ID EP525390
- DOI 10.21276/apjhs.2018.5.2.40
- Views 177
- Downloads 0
A study of titanium elastic nailing system in paediatric femur fractures
Introduction: Treatment of fracture as such at all age groups has revolutionized today along with rapid development in bioengineering science. This has altogether changed the approach towards treatment of fractures keepi...
Closed reduction and internal fixation with kirschner wires for supracondylar fracture humerus in children
Background: Supracondylar fracture of humerus is the commonest injury around elbow in children. It constitutes about 60% of all the fractures about the elbow in children. Aim: To evaluate the results of supracondylar fra...
Study of Factors associated with anaemia in pregnant females belonging to rural Haryana
Anemia is the most common nutritional deficiency disorder found in about 56% of all women living in developing countries as per World Health Organization. It is the second most common cause in India and is responsible f...
Clinical study of non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus
Introduction: Hepatic steatosis may range from a 'benign' indolent deposition of fat to severe lipotoxicity-induced steatohepatitis with necrosis inflammation known as nonalcoholic steatohepatitis (NASH)].NASH is an over...
The most frequently extracted teeth type: a retrospective cross-section study at Ndola teaching hospital, low cost dental clinic, Zambia
Background: The purpose of this study was to investigate the most commonly extracted teeth type at Ndola teaching hospital low cost dental clinic from March 2017 to April, 2017. Methods: During a 3-month period, data on...