Gastroretentive drug delivery systems a potential approach for antihypertensive drugs: An updated review
Journal Title: Asian Pacific Journal of Health Sciences - Year 2018, Vol 5, Issue 2
Abstract
Oral drug delivery system (DDS) is the preferred route of administration of drugs, but poor bioavailability (BA) of orally administered drugs is still a challenging one, though extensive advancements in drug discovery process are made. Drugs with narrow absorption window in the gastrointestinal tract have poor absorption. Gastric emptying of dosage forms is an extremely variable process and ability to prolong and control the emptying time is a valuable asset for dosage forms, which reside in the stomach for a longer period of time than conventional dosage forms. Therefore, gastroretentive DDSs (GRDDSs) have been developed, which prolong the gastric emptying time. Most of the antihypertensive drugs have short half-life, short gastric residence time, low BA, and narrow absorption window. GRDDS can be a viable option for management of hypertension for several antihypertensive drugs. Several techniques such as floating DDS, low-density systems, raft systems, mucoadhesive systems, high-density systems, super porous hydrogels, and magnetic systems have been employed. These forms are expected to remain buoyant on gastric content without affecting the intrinsic rate of emptying. This results in prolonged gastric retention time of floating forms which improve BA of drug and also improve clinical situations. Prolonged gastric retention not only improves the BA and reduces drug waste but also improves solubility for drugs that are less soluble in a high pH environment. It has applications also for local drug delivery to the stomach and proximal small intestines. Gastroretention helps to provide better availability of new products with new therapeutic possibilities and substantial benefits for patients. Hence, it can be concluded that GRDDS promises to be a potential approach for antihypertensive drugs. This review mainly focuses on the different types of GRDDS used for management of hypertension and also includes the updated compiled study of different antihypertensive drugs explored as GR dosage forms.
Authors and Affiliations
Himmat Singh Chawra
Keywords
Related Articles
- EP ID EP525390
- DOI 10.21276/apjhs.2018.5.2.40
- Views 201
- Downloads 0
A study to assess the level of knowledge regarding prevention of PIH among antenatal primi gravida mothers in selected hospital, Dehradun, Uttarakhand, India.
Background: Lo, children are a heritage of the lord and the fruit of the womb is his reward. “Bountiful birth and human being born brings us into the spirit of creation, where the human spirit is courageous and brave a...
Developing adolescent health-risk behavior instrument using Delphi method
Background: There are a number of challenges in developing a reliable and valid instrument on health risk behaviour of adolescents because adolescents are reluctant to disclose negative health behaviour. This research us...
Study on comparison of maternal and fetal outcome in hypothyroid pregnancies with and without hypertension: a controlled case study
Background: Incidence of subclinical hypothyroidism is 2.3% of pregnancies and overt hypothyroidism being 0.2%.Further incidence of hypertension one of the complications of maternal hypothyroidism strongly correlates wit...
A study on probable correlation of AST/ALT (De Ritis) ratio with the advancement of underlying severity of alcoholic liver disease in the North East Indian population
Background: Alcohol consumption has been linked with one of the most common causes of liver disease, and the AST/ALT (De Ritis) ratio has emerged as a useful indicator for its diagnosis. Our study is on patients of alcoh...
Placental Abruption: An Obstetricians Nightmare – A Study of Risk Factors and Maternofoetal Outcomes at Two Tertiary Care Teaching Hospitals in South India
Background:Abruptio placenta is a dire obstetric emergency with potentially life threatening consequences to the mother and the baby. Methods:A prospective observational study was conducted over a period of 30 months at...