GASTRORETENTIVE MUCOADHESIVE MICROSPHERE: A REVIEW
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2012, Vol 2, Issue 4
Abstract
The current article focuses on the principles of mucoadhesive drug delivery systems based on adhesion to biological surfaces that are covered by mucus. In recent years scientific and technological advancements have been made in the research and development of Mucoadhesive Microsphere by overcoming physiological adversities like short gastric residence times and unpredictable gastric emptying times. Gastroretentive drug delivery systems are the systems which are retained in the stomach for a longer period of time and thereby improve the bioavailability of drugs. Different approaches for Gastroretentive dosage forms include floating, expanding or swelling, bioadhesive or mucoadhesive and high/low-density systems. The Mucoadhesive Microsphere should be primarily aimed to achieving more predictable and increased bioavailability of drugs. Prolonged gastric retention improves bioavailability, reduces drug waste, useful for drugs acting locally in the GIT, drugs which are poorly soluble and unstable in intestinal fluids. These systems are advantageous in improving GIT absorption of drug with CR due to specific site absorption limitations. By using mucoadhesive hydrogels as drug carriers is given. Techniques that are frequently used to study the adhesion forces and physicochemical interactions between hydrogel, mucus, and the underlying mucosa are reviewed. Typical examples of applications of mucoadhesive hydrogels to mucosal routes of delivery are given. Various methods of preparation, evaluation test, application. Factors affecting, polymer used and mechanism of bioadhesion are discussed here. Mucoadhesive drug delivery systems is one of the most important novel drug delivery systems with its various advantages and it has a lot of potential in formulating dosage forms for various chronic diseases.
Authors and Affiliations
Madhav S. Mule, Mr. R. V. Kshirsagar
Keywords
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