Gelam honey increases antioxidant enzyme activity in young rat cardiac mitochondria
Journal Title: International Journal of Biomedical and Advance Research - Year 2017, Vol 8, Issue 2
Abstract
Objective: The aim of this study is to determine the effect of gelam honey on antioxidant enzyme activity in cardiac mitochondria of young and aged rats. Methods: Twenty-four male Spraque-Dawley rats were divided into young (2 months) and aged (19 months) groups. Each group was further divided into control (fed with plain water) and supplemented with 2.5 g/kg body weight of gelam honey for 8 months. Results: Gelam honey increases cardiac manganese superoxide dismutase (MnSOD) and glutathione peroxidase (GPx) activities in young. Malondialdehyde (MDA) level was reduced in gelam honey supplemented young group. Gelam honey increases cytochrome oxidase activity in the young group compared to control. Conclusions: Gelam honey reduces the oxidative damage and increase mitochondrial function by increasing antioxidant enzymes and cytochrome oxidase activity in the young group.
Authors and Affiliations
Siti Maisarah Hasenan, Zulaikha Sahhugi, Zakiah Jubri
Keywords
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- EP ID EP383697
- DOI 10.7439/ijbar.v8i2.367
- Views 103
- Downloads 0
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