Gemcitabine Induced Drug Rash with Eosinophilia and Systemic Symptoms: Dress Syndrome: A Case Report
Journal Title: Scholars Journal of Medical Case Reports - Year 2018, Vol 6, Issue 11
Abstract
Drug Rash with Eosinophilia and Systemic Symptoms, currently considered as a systemic reaction with a life-threatening and drug-induced visceral manifestation, has never been described with a chemotherapy drugs. A 52 years-old women with metastatic uterine leiomyosarcoma under chemotherapy second line gemcitabine, presents an extensive erythema with a 38 c° fever, two weeks after chemotherapy. The laboratory studies revealed a mild increase of inflammatory markers, mild anemia, and hyper-leukocytosis and hepatic cytolysis. The histology of skin’s biopsy finds an important lymphocytic infiltrate. The diagnosis is Drug Rash with Eosinophilia and Systemic Symptoms: DRESS syndrome. The patient was treated with corticosteroid therapy, with favorable evolution, the gemcitabine was permanently discontinued. The exact cause is unknown, most likely polyfactorial, It is described as a genetic predisposition. The definitive discontinuation of the drug product in question and systematic emergency corticosteroid therapy is compulsory.
Authors and Affiliations
Mehdi Toreis, Rachid Tanz, Aziz Bazine, Choukri Elm’hadi, Mohamed Amine Azami
Keywords
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