GEN-XPERT® MTB/RIF Contribution in the Diagnosis of Pulmonary Tuberculosis with a Negative Bacilloscopy in Kinshasa (DRC)
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 4
Abstract
Background: Democratic Republic of Congo (DRC) is one of the 22 countries most affected by tuberculosis in the world. The diagnosis of tuberculosis is mainly based on direct microscopy after Ziehl-Neelsen staining. Cases with negative microscopy follows the algorithms adopted in the World Health Organization's guide. Objective: To compare the contribution of GEN-Xpert® to culture for the diagnosis of tuberculosis among clinically diagnosed cases (TPM0). Materials and Methods: In a cross-sectional study of all cases of smear-negative tuberculosis detected at two screening centers in the City of Kinshasa between July 2013 and May 2014. The samples were analyzed by GEN-Xpert® and cultured on Solid medium (LJ) used as standard Gold. Results: The study included 347 smear-negative patients. Positivity rate was 29.1% (95% CI 33.9-43.3) for culture (LJ) and 32.9% (95% CI 36.7-46.6) for GEN-Xpert® MTB / RIF. The sensitivity of GEN-Xpert® by comparison was 93.1%. Rifampicin resistance and multidrug resistance were 9.9% (10). Sensitivity and specificity for detection of resistance to rifampicin was 100%. Conclusion: The choice of a sensitive and rapid test increases the detection rate of TB cases in general and especially in subjects whose direct smear examination is negative.
Authors and Affiliations
Kabedi Bajani MJ, Kayembe Ntumba JM, Kashongwe Munogolo Z, Bisuta Fueza S, Mbaya Kalumba P, Taba Kalulu M, Muyembe Tamfum JJ
Keywords
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- EP ID EP546830
- DOI 10.21276/ijmrp.2017.3.4.033
- Views 107
- Downloads 0
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