Gene blaCTX‑M Mutation as Risk Factor of Antibiotic Resistance
Journal Title: Indonesian Journal of Clinical Pharmacy - Year 2017, Vol 6, Issue 2
Abstract
Currently there are more than half from all antibiotics used in the world which is belong to β lactam group, but clinical effectiveness of the antibiotics are limited by antibiotic resistance of microorganisms as causative agents from infectious diseases. Several resistance mechanisms for Enterobacteriaceae are mostly caused by enzymatic hydrolysis of antibiotics specific enzymes, called β lactamases. β lactamases represent a large group of enzyme which is genetically and functionally different as extended-spectrum β-lactamase (ESBL) and known as greatest threat of resistence. Plasmid localization from the encoded gene and enzyme distribution among the pathogen increases every year. Most widespread and clinically relevant ESBL are class A ESBL of Temoniera (TEM), Sulphydryl variable (SHV) and Cefotaxime (CTX-M) types. The purpose of this review was to analyze variant of blaCTX-M gene which cause the most increase incidence of antibiotic resistance. The methods of this review were data-based searching based on Pubmed, Scopus and Google Scholar, without limitation of index factor by using the keyword “blaCTX-M”, “Extended‑spectrum β‑lactamase”, and “antibiotic resistance”. The conclusion of the review is CTX-M type ESBL have replaced TEM and SHV type as dominant enzyme in last decade. ESBL produced by Klebsiella pneumoniae have emerged as one of major nosocomial pathogens. Nosocomial infection caused by CTX-M-15 in Klebsiella pneumoniae dramatically increased in recent years.
Authors and Affiliations
Devinna Kang, Rano K. Sinuraya, Tina Rostinawati, Rizky Abdulah
Keywords
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- EP ID EP369713
- DOI 10.15416/ijcp.2017.6.2.135
- Views 85
- Downloads 0
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