Gene Environment Interaction–A White Elephant? or An Elephant in the Room?
Journal Title: Psychology & Psychological Research International Journal - Year 2017, Vol 2, Issue 4
Abstract
Genomic information can be considered as “codes” which can’t be altered throughout the lifespan1. With the advent of Genome wide association studies (GWAS), the gene-environment interaction is gaining importance in correlating the endophenotypes of psychological abnormalities with genomic variations. The environmental information collected at the time of disease onset can be matched with DNA information to predict vulnerability in disease cohort. Differences between twin heritability studies and single nucleotide polymorphism heritability studies (“heritability gap”) emphasize the key role of “nurture” in the pathophysiology of mental disorders2. In addition, Mendel’s second law (law of random assortment) can serve as a useful tool in studies analyzing geneenvironment interactions as they help in stratifying patients according to genetic variants.
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