Gene frequencies and polymorphism of the MNS blood group system in the Han population of voluntary blood donors in Suzhou
Journal Title: Chinese Journal of Blood Transfusion - Year 2025, Vol 38, Issue 3
Abstract
[Objective] To investigate the antigen and gene frequency distribution of the MNS blood group system in the Han population of voluntary blood donors in Suzhou, and to explore the polymorphism of rare MNS blood group genes, in order to improve the construction of the local rare blood group database. [Methods] A total of 8 034 whole blood samples were randomly collected from Han blood donors at our station from October 2023 to June 2024. The MNS blood group phenotypes were identified using serological methods. Gene frequencies were analyzed and compared with those of ethnic populations in other regions. Rare MNS phenotype samples were subjected to gene sequencing. [Results] The distribution of MNS blood group system phenotypes within the population was as follows: the MM, NN, and MN phenotypes accounted for 23.00%, 27.12%, and 49.88% respectively; the SS, ss, and Ss phenotypes accounted for 0.30%, 90.99%, and 8.70% respectively. The gene frequencies of M, N, S, and s were 0.4794, 0.5206, 0.0465, and 0.9534 respectively. Chi-squared tests confirmed adherence to Hardy-Weinberg equilibrium with P-values of 0.997 and 0.349, showing statistical significance compared to some other regional ethnic populations (P<0.05). Additionally, one rare serological phenotype, S-s-, with a frequency of 0.01%, was identified. [Conclusion] The MNS blood group system in the Han population of voluntary blood donors in Suzhou exhibits polymorphism and regional distribution characteristics. Gene frequencies differ from those observed in other regions of China. It is essential to enhance the establishment of a rare blood type database in Suzhou to provide data support for precise clinical transfusion.
Authors and Affiliations
Zihao XU, Xiaoyan FU, Zhen LIU, Jia JIANG, Yiming JIN
Keywords
Related Articles
- EP ID EP763284
- DOI 10.13303/j.cjbt.issn.1004-549x.2025.03.014
- Views 5
- Downloads 0
Effect of intraoperative cell salvage on allogeneic blood transfusion requirements, coagulation function and electrolytes in postpartum hemorrhage of cesarean section
Objective To explore the effect of intraoperative cell salvage on allogeneic blood transfusion requirements, coagulation function and electrolytes in postpartum hemorrhage patients. Methods A study on postpartum hemorrha...
Chinese expert consensus on clinical application of irradiated blood
Transfusion associated graft versus host disease (TA-GVHD) is a serious transfusion adverse reaction. It is widely believed that transfusion of irradiated blood is the most effective method to prevent TA-GVHD. There are...
Characteristics of elderly apheresis platelet donors and analysis of pre-donation testing results
Objective To study and analyze the characteristics of 56-60 years old apheresis platelet donors and the results of pre-donation blood testing in Tianjin, so as to provide reference for the management of blood stations an...
Annual financial expenditure in 24 domestic blood stations: a comparative analysis
Objective To study the annual financial expenditure in blood stations with different scales, and to establish the regression equation between blood collection units and total expenditure. Methods The annual total expendi...
Quality comparability analysis on production site change of human coagulation factor Ⅷ
Objective To study the quality comparability of human coagulation factor Ⅷ (FⅧ) produced before and after the change of factory site. Methods A comparative study was carried out on quality quantitative indexes, related i...