Gene polymorphism of endothelial NO-synthase, angiotensin-converting enzyme and receptors of angiotensin II type 1 in patients with coronary artery disease and type II diabetes
Journal Title: Медичні перспективи - Year 2013, Vol 18, Issue 4
Abstract
Purpose: to study the clinical manifestations of coronary artery disease (CAD) in patients with diabetes mellitus (DM) II type and the possible association of mutations in the genes of endothelial NO-synthase (eNOS), angiotensin-converting enzyme (ACE) and receptor of angiotensin II type 1 (AT2R1) with the development of type II diabetes in these patients. Mate¬rials and methods. The study involved 318 patients with CAD, of whom 54 (17,0%) patients had type II DM and 264 (83,0%) patients -without diabetes. Study of allelic polymorphism of T-786S of eNOS gene promoter, insertion-deletion (I/D) polymorphism of ACE gene and polymorphism A1166S of AT2R1 gene was performed by polymerase chain reaction. Results. In patients with CAD and DM type II such risk factors as hypertension, obesity, family history with early onset of cardiovascular disease were significantly more common; CAD manifestation occurs at a younger age, myocardial ischemia more often has silent nature. In the presence of type II DM, coronary artery lesions were of diffuse and multivessel character, other vascular pools are often involved in the atherosclerotic process. An independent as¬sociation of type II diabetes with hypertension, obesity, and CC genotype of eNOS gene T-786S polymorphism was identified in patients with CAD. Negative independent influence of ACE gene I/D polymorphism of D allele and AT2R1 gene A1166S polymorphism C allele on renal function in patients with CAD and type II DM was proved.
Authors and Affiliations
L. Yakovleva
Keywords
Related Articles
- EP ID EP141537
- DOI -
- Views 76
- Downloads 0
Airway remodeling in children with asthma, which runs on the background of intracellular infections
The paper provided information on the impact of persistent intracellular infections, including cytomegalovirus, caused by herpes simplex virus I / II types, Epstein-Barr virus, Сhlamydophila pneumoniae and Mycoplasma pne...
Dynamics of parameters of elastic-elastic properties of arterial wall in patients with morbid obesity after conduction of bariatric treatment
According to the World Health Organization, 2.8 million people die every year from diseases associated with overweight or obesity. Abdominal-visceral form is a serious predictor of mortality from cardiovascular disease....
Післяопераційна фібриляція передсердь
Послеоперационная фибрилляция предсердий (ФП) является одним из самых распространенных осложнений после кардиохирургических вмешательств. Она влияет на длительность пребывания в стационаре, частоту возникновения инсульто...
Оцінка загальної фізичної працездатності та аеробної продуктивності за результатами велоергометрії в дівчат 11-14-ти років з ослабленим зором
Средний школьный возраст является критическим периодом развития человека. С целью оценки и сравнения уровня общей физической работоспособности и аэробной продуктивности у девушек 11-14-ти лет, которые имеют ослабление зр...
Modern views on the pathogenesis of hard dental tissues and periodontium lesions and means of their treatment in children with chronic diseases of the gastrointestinal tract
Changes in the mouth covity often reflect regularities of pathogenesis of a number of disease states, and primarily from the digestive tract. Therefore, the purpose of the study was to clarify pathogenesis of certain les...