Gene Polymorphisms of Cytokines IFN γ +874 (A/T), TNF Α-308 (G/A), IL-6 -174 (G/C), L’il-10 -1082(A/G), -819 (C/T) -592 (C/A), TGF-β1 +869 (T /C), +915 (G/C) in Algerian Type 1 Diabetes and Latent Autoimmune Diabetes in Adults (LADA)
Journal Title: Journal of Diabetes and Obesity - Year 2017, Vol 4, Issue 2
Abstract
Background: We aimed to investigate the association between five cytokines IFN gamma 874 A T TNF Alpha -308 G A IL-6 -174 G C L rsquo il-10 -1082 A G -819 C T -592 C A TGF- beta 1 869 T C 915 G C and patients with type 1 diabetes T1D and Latent Autoimmune Diabetes in Adults LADA. Methods: Polymorphisms of cytokine were determined using the Sequence Specific Primers method PCR-SSP in 50 patients and 74 controls. Results: The results showed significantly higher frequency of IFN gamma 874 TA genotype 65 38 vs 45 95 pc 0 046 in T1D vs controls While T allele 56 25 vs 35 14 in LADA vs controls While significantly higher frequency of TNF gamma -308G A A allele 26 92 vs 13 51 in T1D vs controls and significantly higher frequency of GA Genotype 41 6 vs 24 32 in LADA vs controls While the results showed significantly higher frequency of IL-10 -1082 A G G A genotype 65 38 vs 45 95 in T1D and LADA versus control and IL-10 -592 C A C allele 84 vs 68 92 Regarding polymorphisms of IL-6 no significant difference was observed between T1D LADA and controls. Conclusion: These results suggest that the secretion low of IFN- gamma and high secretion of TNF- alpha may play an important role in protection and susceptibility to autoimmune diabetes in the Algerian population
Authors and Affiliations
Rachida Raache
Keywords
Related Articles
- EP ID EP417861
- DOI 10.15436/2376-0494.17.1566
- Views 69
- Downloads 0
Occurrence of Left Ventricular Hypertrophy in Subjects with Metabolic Syndrome: Role of Adiponectin
This study was designed to evaluate the role of total plasma adiponectin ADPN on the occurrence of left ventricular hypertrophy in subjects with metabolic syndrome MetS compared to a control group without MetS The m...
Diabetes Risk Factors for Chronic Kidney Patients
Diabetes Mellitus DM Chronic Kidney Disease CKD and Coronary Heart Disease CHD are in practice a complex medical status which are closely associated and generally coexist This article focuses the diabetes risk f...
Potential New Pharmacological Approaches in Obese Women with Polycystic Ovary Syndrome
Obesity is frequently present in women with polycystic ovary syndrome PCOS It aggravates the adverse features of the syndrome and increases the metabolic risk in this population Weight management by life style interv...
Alstrom Syndrome with a Mutation in Exon8 (C.4746C > A) of Alstrom Syndrome Protein 1 Gene: The First Case Report and Literature Review
Alström syndrome (AS) is a rare, autosomal recessive disorder characterized by progressive cone-rod dystrophy, childhood obesity, sensorineural hearing impairment, type 2 diabetes, hypogonadism, and additional abnormalit...
Association of Salivary and Plasma Glucose Level with Oral Health Status among Type 2 Diabetics in India - A Comparative Study
Background and Objectives: Diabetes is fast gaining the status of a potential epidemic in India with more than 62 million diabetic individuals currently diagnosed with the condition. Biochemical analysis of saliva would...