Genes of tumor necrosis factors and their receptors and the primary open angle glaucoma in the population of Central Russia
Journal Title: International Journal of Ophthalmology - Year 2017, Vol 10, Issue 10
Abstract
"AIM: To examine the association of genetic polymorphisms (-308)G/A TNFα, (+250)A/G Ltα, (+36)A/G TNFR1, (+1663)A/G TNFR2 with the development of primary open angle glaucoma (POAG) among people in Central Russia. METHODS: The study sample included 443 individuals, of which 252 patients with POAG and 191 individuals in the control group. Genotyping of (-308)G/A TNFα, (+250)A/G Ltα, (+36)A/G TNFR1, (+1663)A/G TNFR2 was performed using polymerase chain reaction. The distribution of alleles and genotypes of the studied DNA markers in the groups was examined by 2×2 contingency tables and χ2 with the Yates’s correction for continuity and odds ratios (OR) with 95% confidence intervals (CI). RESULTS: Allele (-308)G TNFα (Р=0.01, OR=1.78, 95%CI 1.12-2.85) was identified as a risk factor for POAG. Homozygotes (-308) AA TNFα are at a lowest risk for development of the disease (Р=0.01, OR=0.0005). The following combination of genetic variants of cytokines were associated with a reduced risk of POAG: (+1663)A TNFR2 and (+250)G Ltα (OR=0.34) CONCLUSION: Genetic polymorphisms (-308)G/A TNFα, (+250)A/G Ltα, (+1663)A/G TNFR2 associated with the development of POAG in the population of Central Russia."
Authors and Affiliations
Evgeny Reshetnikov
Keywords
Related Articles
- EP ID EP594122
- DOI 10.18240/ijo.2017.10.02
- Views 35
- Downloads 0
Comment on “Anterior lamellar recession for management of upper eyelid cicatricial entropion and associated eyelid abnormalities”
Comment
Choroidal neovascularization post macular surgery: a case series
Letter to the editor
Multimodal imaging of the carriers of choroideremia and X-linked retinitis pigmentosa
Letter to the editor
Post-miosis changes in the anterior chamber structures in primary and lens-induced secondary chronic angle-closure glaucoma
To evaluate post-miosis changes in the anterior chamber structures in various angle-closure glaucomas (ACG). Totally 14 eyes of primary chronic angle-closure glaucoma (PCACG), 12 eyes of lens-induced secondary chronic an...
The Malaysian cataract surgery registry: incidence and risk factors of postoperative infectious endophthalmitis over a 7-year period
"AIM: To report the incidence, risk factors and visual outcomes for postoperative endophthalmitis (POE) based on 7-year data from the Malaysian Ministry of Health Cataract Surgery Registry (MOH CSR). METHODS: Data was co...