GENETIC ANALYSIS OF P53 GENE USING UNWEIGHTED PAIR GROUP METHOD WITH ARITHMETIC MEAN AND NEIGHBOR JOINING METHODS.
Journal Title: International Journal of Advanced Research (IJAR) - Year 2018, Vol 6, Issue 5
Abstract
The p53 molecular network is a master regulator of cellular process and control various signaling pathway, including cell apoptosis, senescence, cellular growth and DNA repair mechanism. Many species have evolved with unique environmental and genetic responses, we tested the related hypothesis that the evolutionary dynamics of, and mode of selection on, genes within the p53 network differs between human and other species, and that these differences may underlie the evolution of p53 in different species. The sequence of human tumor protein p53 (TP53), mRNA, complete cds sequence was retrieved from the NCBI in FASTA format and was studied for its relationship and percent similarity within human and others species. Variation in p53 gene in human and comparative analysis were studied in detail. The phylogenetic analysis was performed using unweighted pair group method with arithmetic mean (UPGMA) and neighbor joining (NJ) methods and revealed the relationships and percent similarity of Homo sapiens TP53, mRNA, complete cds among different organisms especially with monkey, guinea pig, golden hamster, tupaia, whale, rabbit, pig, cat, sheep and cattle. We observed that positive selection of TP53 gene during the divergence of different species during evolution.
Authors and Affiliations
Auwalu Aliyu, Arindam Bhattacharjee, Bahman Khalid
Keywords
Related Articles
- EP ID EP296023
- DOI 10.21474/IJAR01/7066
- Views 85
- Downloads 0
MANAGEMENT OF DECLINING SOYMEAL TRADE FROM INDIA: AN ANTHROPOCENE PROTEIN SUPPLEMENT.
The soybean meal is one of the major foreign exchange earners in the export basket for India due to growth in demand for feeds of bovines, poultry, aqua and swine in Asia and Europe. Currently soybean meal export from In...
ANALYSIS OF EARLY WARNING SYSTEM SCORE IMPLEMENTATION AT INPATIENT ROOM IN SILOAM HOSPITALS BALIKPAPAN.
This study aims to analyze the implementation of EWS according to standards and the factors that influence the implementation of EWS inpatient care Siloam Hospitals Balikpapan. The object in this study was Inpatient Room...
ACCOUNT RECEIVABLE FRAUD: THE ROLE OFINTERNAL CONTROL SYSTEM.
Background:-This study was conducted to analyze the effectiveness of the internal control system on the collection of accounts receivable with the aim to prevent the fraud. Accounts receivable are very fraudulent account...
QUANTUM PROBABILITY IN THE FRAMEWORK OF PHILOSOPHY.
In wave mechanics of quantum theory, the involved wave function in the Schro ̀ˆdinger equation is treated as the probability of deflected particles in some spatial region, which is fundamentally different with that of the...
PSYCHOLOGICAL BARRIERS TO LEARNING EFL LISTENING AND SPEAKING AT THE HSC LEVEL: A STUDY IN DHAKA DIVISION, BANGLADESH.
The study aimed at exploring the psychological factors affecting EFL listening and speaking at the HSC level. The researcher primarily reviewed extensive literature in the respective field and finally selected 12 HSC stu...