Genetic and Molecular Aspects of Ischemic Stroke
Journal Title: International Journal of Current Science Research and Review - Year 2024, Vol 7, Issue 07
Abstract
Stroke remains a leading cause of disability and death worldwide, with significant public health implications. Ischemic stroke is classified into various subtypes based on etiology, including large-artery atherosclerosis, small-vessel occlusion, and cardioembolism. The middle cerebral artery is often the most affected. The concept of the ischemic core and penumbra is crucial in understanding stroke pathology, where the core suffers irreversible damage, and the penumbra is at high risk if reperfusion is not timely. Genetic predispositions play a significant role in ischemic stroke, with heritability estimates around 37.9%. Monogenic causes account for 1-5% of cases, while polygenic factors are more prevalent. Genome-wide association studies (GWAS) have identified numerous genetic loci associated with ischemic stroke, revealing the complex genetic architecture of the disease. Molecular pathways such as neuroinflammation, excitotoxicity, oxidative stress, apoptosis, and autophagy are involved in the pathophysiology of ischemic stroke. Understanding these pathways offers potential therapeutic targets. This review aims to synthesise recent genetic studies and provide insights into future directions for research and clinical practice in ischemic stroke, emphasising the importance of personalised medicine and targeted therapies.
Authors and Affiliations
Pinchada Wongtanate,
Keywords
Related Articles
- EP ID EP740338
- DOI 10.47191/ijcsrr/V7-i7-38
- Views 23
- Downloads 1
Cloud-Native Data Science for Edge Computing and IoT Applications
The use of edge computing and the Internet of Things are now considered essential subcategories of contemporary data systems. There is a new wave of data science application deployment approaches and management modularit...
The Correlation between the Awareness of the Dangers in Smartphone Radiation and Sleep Quality among High School Students in Thailand
Despite smartphones’ critical benefits in several aspects of living in this generation, their emissions of radiation exert profound effects on the physical health of the affected individuals, including heightened risks o...
Integrated Marketing Communication Strategy to Increase Brand Equity of BPJS Kesehatan
BPJS Kesehatan, the implementing body of the JKN Programme, is confronted with the challenge of maintaining program sustainability due to a significant number of inactive participants in the PBPU segment, a situation pri...
Factors That Influencing Employee’s Wellbeing during Pandemic
The purpose of this paper is to examine the relationship between diversity, psychosocial, and employee wellbeing as an impact of implementing flexible working arrangements during the COVID-19 period in 2022. The results...
The Effectiveness of Project-Based Learning Model on Critical Thinking Skills in Grade IV Elementary School on Fraction Number Material in Bantul District
Project Based Learning is one of the learning models that provides space for students to explore knowledge. The purpose of this research is to find the effectiveness of Project Based Learning (PjBL) on the development of...