Genetic background of aberrant thermogenin expression (UCP1) in obesity leading to metabolic syndrome
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2016, Vol 70, Issue
Abstract
Cardiovascular and metabolic disturbances individually and interdependently lead to chronic pathological conditions observed in cardio-metabolic diseases (CMDs). In Europe, the morbidity and mortality caused by cardiovascular disease are the highest among all diseases. Therefore, it seems important to search for new and alternative therapies for obesity, which is the main cause of type 2 diabetes (T2D) and cardiovascular disease (CD). Great attention has been paid to the role of brown adipose tissue in fat burning and the possibility of transformation of the white adipose tissue to cells with brown adipose tissue function as a potential form of treatment of obesity. The best-characterized marker of brown adipose tissue is uncoupling protein 1 (UCP1), which has the ability to dissipate energy as heat in the process called non-shivering thermogenesis. Numerous studies have shown that altered expression of this protein can lead to disturbances in fat metabolism. One possible reason for the aberrant expression of UCP1 may be inherited variations in the gene encoding that protein. Therefore, several studies investigating the role of polymorphisms in the gene encoding UCP1 in susceptibility to obesity or metabolic syndrome have been performed. Here we summarize the results of studies describing the associations between the UCP1 gene polymorphisms A-3826G, A-1766G, Met229Leu and Ala64Thr and polymorphism Trp64Arg in the β3-AR gene, their correlations and their associations with the occurrence of metabolic syndrome.
Authors and Affiliations
Małgorzata Stosio, Agata Witkowicz, Anna Kowalska, Lidia Karabon
Keywords
Related Articles
- EP ID EP206092
- DOI -
- Views 104
- Downloads 0
Synteza cytokin na poziomie komórkowym przez limfocyty T u myszy BALB/c i C57BL/6 zakażonych wirusem ektromelii
Wstęp: Przedmiotem pracy było określenie syntezy IFN-γ, IL-2, TNF-α (Th1/Tc1) oraz IL-4 (Th2/Tc2) na poziomie pojedynczych limfocytów T CD4+ i T CD8+ w przebiegu zakażenia myszy BALB/c i C57BL/6 szczepem Moscow wirusa e...
Starzenie się organizmów prokariotycznych
Jeszcze do niedawna sądzono, że proces starzenia się jest cechą wyłącznie komórek i organizmów eukariotycznych. Niedawne badania przeprowadzone na bakteriach Caulobacter crescentus wykazały jednak, że ich dimorficzny cyk...
Selected aspects of Chlamydophila pneumoniae infections
Chlamydophila pneumoniae was taxonomically separated from strain TWAR – an abbreviation of the strain isolated from humans TW-183 (material from the eye of a child in Taiwan in 1965) and AR-39 (material from a student’s...
Nanostructures: General information. The use of nanoobjects in medicine and cosmetology
The general tendency towards the miniaturization of technological systems and materials has prompted intensive development of nanotechnology. It is a quickly developing area of science devoted to the production and appli...
Białka mleka ludzkiego zaangażowane w procesy immunologiczne
Mleko matki zawiera wiele cząsteczek (m.in. białka, węglowodany, lipidy, związki nieorganiczne), które dostarczają noworodkom podstawowych składników budulcowych w pierwszym okresie ich życia. Skład jakościowy związków o...