Genetic Determinants of Type 2 Diabetes in Asians
Journal Title: International Journal of Diabetology & Vascular Disease Research (IJDVR) - Year 2015, Vol 0, Issue 1
Abstract
Type 2 diabetes (T2D) has become a major health problem throughout the world and the epidemic is particularly severe in Asian countries. Compared with European populations, Asians tend to develop diabetes at a younger age and at much higher incidence rates given the same amount of weight gain. Genome-wide association studies (GWAS) have identified over 70 loci associated with T2D. Although the majority of GWAS results were conducted in populations of European ancestry, recent GWAS in Asians have made important contributions to the identification of T2D susceptibility loci. These studies not only confirmed T2D susceptibility loci initially identified in European populations, but also identified novel susceptibility loci that provide new insights into the pathophysiology of diseases. In this article, we review GWAS results of T2D conducted in East and South Asians and compare them to those of European populations. Currently identified T2D genetic variants do not appear to explain the phenomenon that Asians are more susceptible to T2D than European populations, suggesting further studies in Asian populations are needed.
Authors and Affiliations
Qi Q
Effect of Oral Infections on Serum Creatinine Levels in Diabetic Rats
Aim: The aim of this study was to evaluate the relationship between pulpal and/or periodontal disease and serum creatinine levels in a rat model of diabetes mellitus. Methods: Eighty male rats (Rattus norvegicus albinus,...
Severity of Nonalcoholic Fatty Liver Disease is Associated with Development of Metabolic Syndrome: Results of a 5-Year Cohort Study
Aims: Nonalcoholic fatty liver disease (NAFLD) is considered to be a hepatic manifestation of metabolic syndrome (MS). However, a few studies have examined the effect of NAFLD on the development of MS. We evaluated the r...
Vietnamese may develop type 2 diabetes with smaller increases in body mass index and waist circumference than Taiwanese
Background: Obesity is associated with development of diabetes. However, it seems that the level of obesity in association with diabetes may differ from country to country. Aim: To compare BMI and waist circumference in...
Walking Economy is Impaired in Older Men and Women with Type 2 Diabetes
Objective: We compared the walking economy in older participants with and without type 2 diabetes. Methods: Walking economy was determined in 115 older participants with type 2 diabetes and 130 older control participants...
Pathophysiologic Aspects of Hypertension
Hypertension is defined as a sustained increase in blood pressure. Historically, the level of blood pressure designating hypertension has been a systolic blood pressure of 140 mm Hg or more and/or a diastolic blood press...