Genetic markers in HLA region to identify patients with tuberculosis risk, in RA subjects
Journal Title: International Journal of Clinical Rheumatology - Year 2019, Vol 14, Issue 1
Abstract
Objetive: To identify the patients with RA at highest risk of TB, prior to the use of biological therapy antiTNF. Method: We carried out a study of two phases considered three groups, in the first we performed a case and control study in the Hospital Juárez de México, in the second phase, the results of phase one were analyzed with those obtained in the group of patients identified with Poncet´s disease. We compared the classes I and II of the HLA of patients naïve to biologic treatment with healthy controls. Result: We have identified several candidate alleles that will help to advance the personalized treatment of RA that takes into account the genetic risk to develop TB, particularly the alleles B27 and DQB1*0301. Conclusion: Patients with RA have an increased risk to develop TB and severe complications derived from it. This infectious process is related to the use of biologic.
Authors and Affiliations
Gustavo Lugo Zamudio, Rosa Elda Barbosa Cobos, Dolores Delgado-Ochoa, Rodrigo Huerta-Gutiérrez, Julio Granados Arreola
Keywords
Related Articles
- EP ID EP614570
- DOI -
- Views 42
- Downloads 0
Lower ratings of pain intensity in older adults lead to underestimation of disease activity in patients with rheumatoid arthritis
Background: To investigate the influence of age on the components of the 28-joint Disease Activity Score (DAS28)-C-Reactive Protein (CRP) in patients with Rheumatoid Arthritis (RA) and whether DAS28-CRP can be equally in...
Nanomedicine in rheumatology: A new field in the diagnosis and therapy of rheumatic diseases
Nanomedicine is a prolific and vastly expanding field of medicine rendering important new avenues to improve diagnosis and treatment of human maladies. However, safety of the nanomaterials and therapeutic agents must be...
Serum vitamin D in Egyptian patients with systemic lupus erythematous and its association with lupus nephritis
Aim: To assess VD levels in serum of patients with LN in comparison with patients with extra-renal lupus and healthy controls, and to assess the relation between VD levels and the various clinical and laboratory disease...
Association of weight loss with improved disease activity in patients with rheumatoid arthritis: A retrospective analysis using electronic medical record data
Background: Objective: To evaluate the association between weight loss and rheumatoid arthritis (RA) disease activity. Methods: We conducted a retrospective cohort study of RA patients seen at routine clinic visits at a...
Methotrexate and leflunomide survival in patients with psoriatic arthritis
Abstract:The objectives of this study were to estimate the survival rate of the most frequently used DMARDs in a cohort of PsA patients and factors associated with a higher survival rate. Methods: Patients ≥ 18 years of...