Genetic markers in HLA region to identify patients with tuberculosis risk, in RA subjects
Journal Title: International Journal of Clinical Rheumatology - Year 2019, Vol 14, Issue 1
Abstract
Objetive: To identify the patients with RA at highest risk of TB, prior to the use of biological therapy antiTNF. Method: We carried out a study of two phases considered three groups, in the first we performed a case and control study in the Hospital Juárez de México, in the second phase, the results of phase one were analyzed with those obtained in the group of patients identified with Poncet´s disease. We compared the classes I and II of the HLA of patients naïve to biologic treatment with healthy controls. Result: We have identified several candidate alleles that will help to advance the personalized treatment of RA that takes into account the genetic risk to develop TB, particularly the alleles B27 and DQB1*0301. Conclusion: Patients with RA have an increased risk to develop TB and severe complications derived from it. This infectious process is related to the use of biologic.
Authors and Affiliations
Gustavo Lugo Zamudio, Rosa Elda Barbosa Cobos, Dolores Delgado-Ochoa, Rodrigo Huerta-Gutiérrez, Julio Granados Arreola
Keywords
Related Articles
- EP ID EP614570
- DOI -
- Views 35
- Downloads 0
The correlation between blood lead levels and knee osteoarthritis: a preliminary Egyptian study
Background: Lead is a common ubiquitous environmental pollutant. The increasing prevalence of knee Osteoarthritis (OA) among young patients is suggestive of a possible contribution of environmental factors such as lead....
Psychological status is associated with drug efficacy in patients with ankylosing spondylitis
Background: Quality of life in patients with Ankylosing Spondylitis (AS) is significantly associated with psychological disorders, such as depression and anxiety. Effective prevention and control of depression and anxiet...
Necrotizing autoimmune myopathy: an emerging entity in the spectrum of inflammatory myopathies
Background: Necrotizing autoimmune myopathy is a relatively newly recognized rare form of idiopathic inflammatory myopathy. It presents clinically with symmetrical proximal muscle pain and weakness, associated with a mar...
T helper 17 cells and interleukin-17 in patients with rheumatoid arthritis
Rheumatoid Arthritis (RA) is one of the most prevalent autoimmune disease which may lead to a shorter life expectancy and lessened personal satisfaction. it is driven by effector T cells, particularly Th17 cells which po...
Treatment of early rheumatoid arthritis with certolizumab pegol after failure of diseasemodifying antirheumatic drugs: a report of two cases
Rheumatoid arthritis is a severe systemic inflammatory disease, characterized by polyarticular synovitis and subsequent structural changes to the cartilage. Diagnosis and treatment in the early disease stages are extreme...