Genetic pheochromocytoma/paraganglioma– A review

Journal Title: Scientific Journal of Medical Science - Year 2013, Vol 2, Issue 11

Abstract

The prevalence of pheochromcytoma in hypertensive patients is less than 1%.Most PHEOs occur sporadically, but a substantial proportionmay be associated with germ line mutations of genes predisposing to thedevelopment of familial syndromes like multiple endocrineneoplasia(MEN),Von-Hippel Lindau(VHL) disease,neurofibromatosis type 1(NF-1),familial paraganglioma/pheochromocytoma (PGL/PHEO) related to geneticmutation encoding the mitochondrial protein succinate dehdrogenase sub units(SDH-BCD) .Screening for genetic mutation is imperative as it may add more onmanagement and surveillance of this patients .This review summarize therelevant data related to this fascinating clinical entity.

Authors and Affiliations

F. B. Pambinezhuth| National Diabetes and Endocrine center –Royal hospital, Muscat Oman.

Keywords

Related Articles

Carotid intima-media thickness seems not to correlate with the severity of diabetic retinopathy

Diabetic retinopathy and vascular complications of diabetes have been studied for decades, with the aim of defining better their pathogenesis and time profile. The severity of diabetic retinopathy has clear consequences...

Giant cell tumour of clavicle

We report a case of Osteoclastoma in Clavicle bone in a young adult. Osteoclastoma usually occurs in juxta-articular ends of the long bones of skeletally mature individuals. Its occurance at lateral end of clavicle, a fl...

Acute poisoning with copper sulphate in a young lady

Ingestion ofcopper sulphate is an uncommon form of poisoning which is usually reported inIndian subcontinent. This poisoning can lead to life threatening seriouscomplications like acute intravascular hemolysis, renal fai...

Title- comparison of oxytocin, methergin and carboprost in active management of third stage of labour

To compare the efficacy of 10 units oxytocin, 0.2 mg methylergometrine and 250 microgram carboprost in the active management of third stage of labour. A randomized comparative study enrolling 300 women was donein the Dep...

Estimation of serological marker for the diagnosis of rheumatoid arthritis

Objectives: Rheumatoid arthritis (RA) is a chronic auto-immune disorder; there is a prominent immunological dysfunction in the joints and many other tissues by accumulation of chronic inflammatory cells including T and B...

Download PDF file
  • EP ID EP1251
  • DOI 10.14196/sjms.v2.i11.1023
  • Views 407
  • Downloads 29

How To Cite

F. B. Pambinezhuth (2013). Genetic pheochromocytoma/paraganglioma– A review. Scientific Journal of Medical Science, 2(11), 208-211. https://europub.co.uk/articles/-A-1251