GENETIC POLYMORPHISMS ASSOCIATED WITH CHLOROQUINE RESISTANCE AMONG PLASMODIUM FALCIPARUM ISOLATES FROM ALJUNAYNAH DISTRICT, WEST DARFUR STATE, SUDAN
Journal Title: World Journal of Pharmaceutical and Medical Research - Year 2018, Vol 4, Issue 12
Abstract
Chloroquine CQ resistance has been shown to be associated with point mutations in Pfcrt and Pfmdr1. These genes encode for digestive vacuole transmembrane proteins Pfcrt and Pgh1 respectively. Polymorphisms were examined in these genes in25 isolates from Aljunaynah, west Darfur state, Sudan. The isolates were subjected to PCR-RFLP analysis for the Pfmdr1 N86Y and Pfcrt K76T mutations. The frequency of mutant allele for CQ pfcrt T 76 was19 (38%) and pfmdr1 Y 86 was 7 (14%). The study concluded that the frequency of chloroquine drug resistance molecular markers were higher in the study area and lower than that reported in other Sudan states. The result necessitates the evaluation of CQ in vivo therapeutic efficacy in endemic areas for more effective malaria control strategies.
Authors and Affiliations
Abdalmoneim M. Magboul
Keywords
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