Genetic Polymorphisms of CYP2C8 in A Healthy Iranian Population
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2014, Vol 4, Issue 10
Abstract
Aim: The aims of this study were to genotype CYP2C8 in an Iranian population and compare their allelic frequencies with other ethnic groups. Study Site and Duration: Biotechnology Department, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran from June 2012 through May 2013. Methodology: CYP2C8 (*1/*2/*3) allelic variants were determined in 200 unrelated healthy Iranian volunteers by real time-polymerase chain reaction (PCR). Results: A total 156 subjects (78%) were homozygous for CYP2C8*1, six subjects (3%) were homozygous for CYP2C8*2 and 38 subjects (19%) were heterozygous CYP2C8*1/*2. CYP2C8*3 was not detected. Discussion and Conclusion: Genotyping indicated no significant (P>0.05) difference between CYP2C8 allelic variant frequencies in an Iranian compared with Burkina Faso population. The Iranian population’s CYP2C8 allelic variation was significantly (P<0.05) different when compared with populations in Portugal, African-American race to Malaysia, Ghana, Zanzibar, Spain, Czech Republic and Sweden.
Authors and Affiliations
Ali Ramazani, Mahsa Ghaffari, Amir Fakhri
Keywords
Related Articles
- EP ID EP349206
- DOI 10.9734/BJMMR/2014/7517
- Views 49
- Downloads 0
Rates and Determinants of Complications Following Trans-Rectal Prostate Biopsy in Enugu, Nigeria
Aims: Analysis of the complications of trans rectal prostate biopsy to establish their rates and determinants. Study Design: Retrospective study. Place and Duration of Study: Departments of Urology University of Nigeria...
Postural Changes during First Pregnancy
Aims: The precise changes in postures of each part of the spine of primigravid women are still ambiguous. This study aimed to find out the spinal curvature and pelvic tilt changes during the first pregnancy. Study Design...
Overview of Blunt Chest Injury with Multiple Rib Fractures
Introduction: Thoracic trauma leading to multiple fractured ribs (MFR) remains common. The significant chest pain of multiple rib fractures can be difficult to manage and can lead to decreased pulmonary function, increas...
Effect of Ramipril Treatment on Proteinuria and Advanced Glycation End Products in Type 2 Diabetes Mellitus Patients with Nephropathy: One Year Follow up Study
Aims: The present study was carried out to evaluate the effect of angiotensin converting enzyme inhibitor (ACEI) therapy on proteinuria and serum advanced glycation end products (AGEs) level in type 2 diabetes mellitus (...
Assessment of Birth Preparedness and Complication Readiness (BP/CR) among Pregnant Women in Orlu Local Government Area of Imo State, Nigeria
Birth Preparedness and Complication Readiness (BP/CR) are very important tenets of Focused Ante-Natal Care (FANC) aimed at reducing maternal morbidity and mortality. This study assessed birth preparedness and complicatio...