Genetic Polymorphisms of CYP2C8 in A Healthy Iranian Population
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2014, Vol 4, Issue 10
Abstract
Aim: The aims of this study were to genotype CYP2C8 in an Iranian population and compare their allelic frequencies with other ethnic groups. Study Site and Duration: Biotechnology Department, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran from June 2012 through May 2013. Methodology: CYP2C8 (*1/*2/*3) allelic variants were determined in 200 unrelated healthy Iranian volunteers by real time-polymerase chain reaction (PCR). Results: A total 156 subjects (78%) were homozygous for CYP2C8*1, six subjects (3%) were homozygous for CYP2C8*2 and 38 subjects (19%) were heterozygous CYP2C8*1/*2. CYP2C8*3 was not detected. Discussion and Conclusion: Genotyping indicated no significant (P>0.05) difference between CYP2C8 allelic variant frequencies in an Iranian compared with Burkina Faso population. The Iranian population’s CYP2C8 allelic variation was significantly (P<0.05) different when compared with populations in Portugal, African-American race to Malaysia, Ghana, Zanzibar, Spain, Czech Republic and Sweden.
Authors and Affiliations
Ali Ramazani, Mahsa Ghaffari, Amir Fakhri
Keywords
Related Articles
- EP ID EP349206
- DOI 10.9734/BJMMR/2014/7517
- Views 83
- Downloads 0
Erupting Odontome- A Compilation of Two Rare Case Reports
Odontomas are the most common type of benign odontogenic tumours; they are asymptomatic and are often discovered during routine radiographs of the jaws. Odontomes can be used as stem cell reservoirs and generally eruptio...
Influence of One-Piece (Monoblock) Fibreglass Post Design on the Fracture Resistance of Extensively Damaged Teeth: An Ex vivo Study
Aims: This study compared fracture resistances of roots restored with one-piece (monoblock) fibreglass post systems having different designs. Study Design: Original Research Paper Place and Duration of Study: Hacettepe...
Treatment of Permanent Teeth with Extensive Apical Periodontitis: 2 Case Reports
Aims: The purpose of the examination of these cases is to maintain the treatments and the managements of teeth with extensive apical periodontitis. Case Presentation: Case 1: A fifteen years old young male patient with a...
Screening for Glucokinase (GCK) Gene Mutation in Gestational Diabetes Women in Western Region of Saudi Arabia
Aim: The study involved screening of three exons of glucokinase gene (7, 8 and 9) to detect mutations at posi¬tions 682A>G, p.T228A, 895G>C, p.G299R and 1148C>A, p.S383X, respectively in Saudi pregnant women with or with...
Disease Surveillance and Notification, Knowledge and Practice among Private and Public Primary Health Care Workers in Enugu State, Nigeria: A Comparative Study
Aims: The study was to compare knowledge, practice of Disease Surveillance and notification as well as ascertain factors that influence it among Health care workers in public and private health centres in Enugu state, Ni...