Genetics of Depression – Frequency of Allelic Variation of Serotonin Transporter Gene (5HTT) Among Patients with Depression
Journal Title: Isra Medical Journal - Year 2018, Vol 10, Issue 3
Abstract
OBJECTIVE: To determine the frequency of serotonin transporter gene (5HTT) allelic subtypes in patients with Depression STUDY DESIGN: Descriptive, cross-sectional study PLACE AND DURATION: Out-Patient Department of Institute of Psychiatry, Benazir Bhutto Hospital, Rawalpindi, in collaboration with Institute of Biomedical and Genetics Engineering, Khan Research Laboratories Hospital, Islamabad, from 20th August 2011 till 20th February 2012 METHODOLOGY: 191 subjects were selected and International classification of diseases (ICD-10) criteria was applied for diagnosing Depression. Blood specimen underwent crystallization, DNA was separated and analyzed for the presence of 5 HTT allele types. Short and large alleles (s/l, l/l and s/s) of serotonin transporter gene (5HTT) were isolated. RESULTS: Frequencies of 5HTT allelic subtypes of short/large (s/l) and large/large (l/l) were found to be higher (35.6% and 34.6%respectively) as compared to short/short (s/s) allele which was less common (29.8%) in comparison to above mentioned subtypes. CONCLUSION: This study found that people who have depression tend to have greater frequencies of short/large (s/l) and large/large (l/l) alleles of Serotonin transporter gene (5HTT). KEY WORDS: Depression, Gene-Environment Interaction, ICD-10, Major Depressive Disorder, Serotonin Transporter Gene - 5HTT, HOW TO CITE THIS: Khan FR, Nizami AT, Gani N, Haq IU. Genetics of Depression – Frequency of Allelic Variation of Serotonin Transporter Gene (5HTT) Among Patients with Depression. Isra Med J. 2018; 10(3): 177-180.
Authors and Affiliations
Faisal Rashid Khan
Keywords
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