Genetics of Growth Hormone Deficiency
Journal Title: Journal of Clinical Research in Pediatric Endocrinology - Year 2009, Vol 1, Issue 1
Abstract
From the initiation of the primordium to the expression of mature growth hormone (GH)1 gene, a variety of genes, transcription factors, signalling pathways, and epigenetic control factors take part in the embryological development of the anterior hypophyseal somatotrophic cells. A defect in this process may result in multiple pituitary deficiency or isolated growth hormone deficiency depending on the temporal or spatial position of the individual factor. This article reviews these factors in a chronological order. This review presents some of these genetic mutations that result in obesity. DOI: 10.4008/jcrpe.v1i1.30
Authors and Affiliations
Ali Topaloğlu
Keywords
Related Articles
- EP ID EP91524
- DOI -
- Views 122
- Downloads 0
The Relationship Between Leptin and Norepinephrine Levels During OGTT in Normotensive and Hypertensive Obese Adolescents <br />
Background/Aims: Studies in adult population have suggested that leptin might play a role in inducing obesity related hypertension mediated by the sympathetic nervous system. This association has not been established for...
Metabolic Syndrome in Childhood: defining the problem
There is a significant increase in the incidence of childhood obesity all over the world which frequently leads to Type 2 diabetes mellitus (T2DM). Several studies have focused on the definitive criteria for diagnosis of...
Foreword
In presenting this first issue of the Journal of Clinical Research in Pediatric Endocrinology (JCRPE), we renew our hopes that in due time this journal will establish its place in the international arena of Pediatric End...
Controversies in the Definition and Treatment of Idiopathic Short Stature (ISS)
The term idiopathic short stature (ISS) refers to short children with no identifiable disorder of the growth hormone (GH)/insulin like growth factor (IGF) axis and no other endocrine, genetic or organ system disorder. Th...
Precocious Puberty and Normal Variant Puberty: Definition, etiology, diagnosis and current management
This review describes several aspects of the management of precocious puberty (PP) and variants in girls and boys. PP is characterized by early pubertal changes, acceleration of growth velocity and rapid bone maturation...