Genetics of Obesity
Journal Title: Journal of Clinical Research in Pediatric Endocrinology - Year 2009, Vol 1, Issue 1
Abstract
The genetic basis of predispositon to obesity has been recognised for a long time. Several single gene-defects in rodents and humans cause the development of obesity. However these are extremely rare and an increase in genetic defects is insufficient to explain the substantial increase in the prevalance of obesity over the past two decades. There is a continuing search for obesity genes. Although single gene mutations in humans are not a major cause of the current obesity epidemic, they support the importance of these genes in the regulation of energy balance. This review presents some of these genetic mutations that result in obesity. DOI: 10.4008/jcrpe.v1i1.34
Authors and Affiliations
İffet Bircan
Foreword
In presenting this first issue of the Journal of Clinical Research in Pediatric Endocrinology (JCRPE), we renew our hopes that in due time this journal will establish its place in the international arena of Pediatric End...
Genetics of Obesity
The genetic basis of predispositon to obesity has been recognised for a long time. Several single gene-defects in rodents and humans cause the development of obesity. However these are extremely rare and an increase in g...
Growth of Children with Type 1 Diabetes Mellitus
Objective: To retrospectively evaluate the effect of type 1 diabetes on growth. Methods: Patients with Type 1 diabetes mellitus (T1DM) followed for at least one year after diagnosis, and without coexisting disorder that...
Diagnosis of Growth Hormone Deficiency: the role of Growth Hormone (GH), Insulin-Like Growth Factor (IGF-I) and IGF-Binding Protein (IGFBP-3)
Despite dramatic changes in the treatment of growth hormone (GH) deficiency from cadaveric pituitary growth hormone to recombinant human growth hormone, the diagnosis of idiopathic growth hormone deficiency remains a cha...
Neonatal Sludge: A finding of congenital hypothyroidism
Congenital hypothyroidism is one of the most urgent diseases of the neonate. When diagnosed and treated at an early stage, its most important complication, mental retardation, is preventable. The signs of congenital hypo...