Genetics to Genomics in Clinical Medicine
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2014, Vol 4, Issue 30
Abstract
Biomedical research and knowledge has grown exponentially since the completion of the Human Genome Project in the year 2000. There has been a gradual shift from ‘genetics’ (study of genes) to ‘genomics’ (study of the whole genome) in medicine. Advances such as sequencing of the human genome, genome enrichment, epigenetics and bioinformatics have transformed the face of translational research and are beginning to have a major impact on clinical practice. In order to take advantage of the full potential of genomic research in clinical practice, clinicians will need to understand and embrace a significant conceptual shift from ‘Mendelian genetics’ to ‘Post Mendelian genomics’. A relative lack of genetics to genomics knowledge has been reported amongst senior physicians in major health plans in the United States. This is also true of physicians practicing in the United Kingdom as reflected in the reports by the British Royal Society (BRS), Wellcome Trust and UK department of Health. While large sections of the academic medical community is driving this conceptual shift, a significant proportion of practicing clinicians are not actively involved in these developments. Here we describe the continuum from genetics to genomics in medicine by giving a brief overview of the shift from single gene disorders and chromosomal aberrations to functional genomics and our current understanding of the more dynamic relationship between genotype and phenotype.
Authors and Affiliations
Vinit Sawhney, Richard Schilling, Benjamin O. Brien
Keywords
Related Articles
- EP ID EP349015
- DOI 10.9734/BJMMR/2014/11175
- Views 66
- Downloads 0
To Compare the Pursuance of Ultrasonic Activation at Distinct Planes of Endodontic Therapy on Filling Superiority of Different Root Canal Sealers
Aim: The purpose of this study was to evaluate the influence of ultrasonic activation at different levels of endodontic therapy on filling quality of various sealers. Materials and Methods: Sixty extracted human single r...
A Simple Method to Forecast Future Bed Requirements: A Pragmatic Alternative to Queuing Theory
Aims: To review the current state of hospital bed planning, and to develop a simple tool to estimate short-term future bed requirements using historical bed occupancy data. Study Design: Analysis of daily bed occupancy b...
Studying the Rate of Physical and Emotional Abuse among Elementary School Students of Isfahan in 2014 and Its Relation with Some of the Cognitive Demographic Characteristics for Better Health Care
Aim: Determining the rate of physical and emotional abuse among elementary school students of Isfahan and its relation with demographic characteristics Place and Duration of the Study: The study was conducted in 12 eleme...
Demographic Profile of Travellers Seeking Reproductive Tourism Services
Reproductive medical tourism is by some accounts a multibillion dollar industry globally. Transnationally, it involves the travel between nations of individuals seeking assisted reproductive technologies in foreign count...
Potential Relationship between Self-Assessed Eating Speed and Recalled Duration of Eating Meals in Apparently Healthy Adults
Background: Self-assessed eating speed was frequently used to assess an individual’s eating speed in previous clinical studies. However, the relationship between self-assessed eating speed and the duration of eating meal...