GENEXPERT - IS IT AN EXPERT IN DIAGNOSIS OF EXTRAPULMONARY TUBERCULOSIS?
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 51
Abstract
BACKGROUND Six countries in Asia account for 60% of the total new tuberculosis cases occurring globally with India leading the count. India accounts for approximately 25% of global incidence of tuberculosis with almost 2 deaths every 3 minutes due to tuberculosis alone. GeneXpert is a comparatively newer diagnostic test for detecting Mycobacterium tuberculosis complex, which uses the PCR to test specimens and simultaneously detects resistance to rifampicin, thus allowing diagnosis of DR-TB within a couple of hours. The present study was conducted to find the sensitivity and specificity of GeneXpert in extrapulmonary samples (lymph node and pleural fluid) and compare the results with those of smear and AFB culture with an aim to provide rapid diagnostic test to patients with suspected extrapulmonary tuberculosis. MATERIALS AND METHODS A retrospective data analysis of reports of extrapulmonary samples (lymph node and pleural fluid) of 45 patients sent for AFB smear, GeneXpert and AFB culture during routine investigations were studied. RESULTS Sensitivity of GeneXpert in lymph node samples was found to be 94.12% and specificity was 30.77% with positive predictive value of 64% and negative predictive value of 80%. The sensitivity of GeneXpert in pleural fluid samples was found to be 60% with 100% specificity. The positive predictive value was 100% and negative predictive value was 83.33%. CONCLUSION The overall sensitivity of GeneXpert was 96.67% with specificity of 100%, positive predictive value of 100% and negative predictive value of 83.33%. Thus, it is a valuable test for diagnosing extrapulmonary tuberculosis at the earliest with an added advantage of detecting resistance for rifampicin.
Authors and Affiliations
Mitali Mukund Nayak, Himanshu Suresh Thakker, Ruhee Gotmare
Keywords
Related Articles
- EP ID EP220231
- DOI 10.18410/jebmh/2017/611
- Views 97
- Downloads 0
DIASTOLIC DYSFUNCTION: A REVIEW
INTRODUCTION Diastolic heart failure is an underestimated pathology. Epidemiological and clinical studies suggest that HF with a preserved ejection fraction will become the more common form of HF which clinicians will en...
ELECTROCARDIOGRAPHIC CHANGES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Chronic Obstructive Pulmonary Disease (COPD) is a common preventable and treatable state characterized by persistent airflow limitation. It is fourth leading cause of chronic morbidity and mortality world over. COPD infl...
A COMPARATIVE STUDY OF HAEMODYNAMIC EFFECTS OF INDUCTION DOSES OF PROPOFOL THIOPENTONE AND PROPOFOL KETAMINE COMBINATIONS
BACKGROUND The commonly used intravenous (I.V.) Induction agents in anaesthetic practice are propofol, Thiopentone, Ketamine. But haemodynamic instability is common like use of ketamine results in tachycardia and hyperte...
A COMPARISON OF DIDACTIC LECTURES TO SELF-DIRECTED LEARNING IN MEDICAL EDUCATION
BACKGROUND Newer learning methods like Self-Directed Learning (SDL) are being experimented in medical education. SDL has been advocated as an effective learning strategy for medical students to achieve competency. MATERI...
COMPARATIVE STUDY OF CLINICAL OUTCOME OF ARTHROSCOPIC ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION BONE PATELLAR TENDON BONE GRAFT V/S HAMSTRING GRAFT
Anterior cruciate ligament is an intra-articular, extra synovial structure present in the central complex of knee joint. It functions in concert with all other anatomical structures in the knee joint to control and limit...