GeneXpert MTB/RIF Assay for Rapid Identifcation of Mycobacterium Tuberculosis and Rifampicin Resistance Directly from Sputum Sample
Journal Title: Journal of Enam Meical College - Year 2017, Vol 7, Issue 2
Abstract
Background: The World Health Organization has endorsed the use of molecular methods for the detection of tuberculosis (TB) and drug resistant TB as a rapid method. In Bangladesh, the Xpert MTB/RIF assay has been implemented into reference laboratories for diagnosis of TB and also MDR TB. Objective: Drug resistant tuberculosis has long been a common problem prevailing in our country. The present study focused on the rapid identifcation of Mycobacterium tuberculosis as well as drug resistance. Materials and Methods: Sputum samples from a total of 107 cases, assumed as multi-drug resistance tuberculosis, were studied through GeneXpert assay. Results: Out of 107 cases, 91 (85.05%) were detected having M. tuberculosis ─ 64 (59.81%) were rifampicin sensitive and 27 (25.23%) were rifampicin resistant. The sensitivity and specifcity of the GeneXpert are 87.64% and 75% respectively. Conclusion: GeneXpert assay can be considered for the rapid diagnosis of drug resistant tuberculosis.
Authors and Affiliations
Nourjahan Laskar, Md Akram Hossain, Jannatul Fardows, Mominur Rahman
Keywords
Related Articles
- EP ID EP36298
- DOI https://doi.org/10.3329/jemc.v7i2.32653
- Views 261
- Downloads 0
Seroprevalence of Anti-HCV Antibody in Patients with Chronic Kidney Disease before Starting Dialysis Therapy
Background: Hepatitis C virus (HCV) infection and chronic kidney disease are common and potentially serious medical problems throughout the world. In recent years, it has become clear that these two conditions are link...
Lupus Vulgaris Causing Nasal Destruction: Rare Presentation in Current Time
A 42-years old lady reported with slowly progressive reddish lesions over the nose, followed by atrophy and ulceration for about 6 years. Clinical examination revealed atrophied, ulcerated, erythematous lesions over cent...
From the Desk of Editor-in-Chief
Not available
A Clinical and Laboratory Profle of Multiple Myeloma
Background: Myeloma, the most common malignant disease of bone, is incurable and occurring with increasing frequency in elderly population. Typical clinical features are weakness, fatigability, bone pain, anemia, renal...
Ultrasonographic Discrimination of Benign and Malignant Breast Lumps with Histopathological Correlation
Background: A lump in the breast is a cause of great concern. High frequency high resolution ultrasonogram helps in its evaluation. With major advances in ultrasonographic technology during the past 20 years, ultrasono...