GENOTOXICITY OF MYTOMYCIN C- CYTOGENETIC STUDY
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 3
Abstract
The present study was undertaken to study genotoxic effect of Mitomycin C at different concentrations for different duration on human chromosomes in search of a dose which will be more effective and less toxic in lymphocytic culture and to find the specificity of its action on human chromosomes in lymphocyte culture. The range of concentration of Mitomycin C (0.05, 0.1, 0.5, 1.0, 2.0, 5.0 μg /ml medium) were used for different durations (24, 72, and 1hour) Genotoxicity was less for low concentration (0.05, 0.1 μg/ml) for long duration (72 hours). Mitomycin C specifically involves chromosome 9, 1 and 16 in chromosomal aberrations. Interchange exchange was the most common chromosomal aberration induced by Mitomycin C. Most commonly involved chromosome in interchange exchange was chromosome 9.
Authors and Affiliations
Dr. Darshna Fulmali, Dr. Sudhir Pandit, Dr. Archana Kannamwar
Keywords
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