Genotypes and allele frequencies of angiotensin converting enzyme (ACE) insertion/deletion polymorphism among Omanis
Journal Title: Sultan Qaboos University Medical Journal - Year 2002, Vol 4, Issue 2
Abstract
Objective: To describe the angiotensin converting enzyme (ACE) genotype frequencies among Omani Arabs. Method: A polymerase chain reaction (PCR) test, based on separation of different size DNA fragments, was developed to test the presence or absence (polymorphism) of a small DNA deletion in the ACE gene. The subjects were 124 Omani Arab students of Sultan Qaboos University, Muscat. Results: The frequency of the I allele was 0.29, while that of the D allele was 0.71. The gene frequency distribution did not deviate from Hardy-Weinberg equilibrium. Conclusions: The frequency of D allele among Omanis is similar to that among other Arabs and Africans, but differs significantly from that among the Japanese and Chinese.
Authors and Affiliations
Ali T. Al-Hinai| Departments of Medicine, College of Medicine & H Sc, Sultan Qaboos University, P.O.Box 35, Al-Khod-123, Sultanate of Oman, Mohammed O Hassan| Department of Physiology, College of Medicine & H Sc, Sultan Qaboos University, P.O.Box 35, Al-Khod-123, Sultanate of Oman, Mehmet Simsek| Department of Biochemistry, College of Medicine & H Sc, Sultan Qaboos University, P.O.Box 35, Al-Khod-123, Sultanate of Oman, Hameeda Al-Barwani| Department of Biochemistry, College of Medicine & H Sc, Sultan Qaboos University, P.O.Box 35, Al-Khod-123, Sultanate of Oman, Riad Bayoumi| Department of Biochemistry, College of Medicine & H Sc, Sultan Qaboos University, P.O.Box 35, Al-Khod-123, Sultanate of Oman
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