EuroPub
Search
Apply

Glomerular and Tubular Functions in Children and Adults with Transfusion-Dependent Thalassemia

Journal Title: Turkish Journal of Hematology - Year 2018, Vol 35, Issue 1

Abstract

This study aimed at assessing renal functions in patients with transfusion-dependent thalassemia (TDT). Fifty patients and 30 controls were enrolled in this prospective study. Serum levels of electrolytes and albumin were measured by a spectrophotometer. Serum levels of cystatin-C and urinary levels of β2-microglobulin were measured by nephelometric method. Thirty-eight patients were receiving deferasirox and 8 were on deferiprone. Serum electrolytes and albumin levels of the patients were found to be within normal ranges. Urinary β2-microglobulin and serum cystatin-C levels were significantly higher in patients than controls. They did not significantly differ between the subgroup of patients on deferiprone and the control group, whereas they were found to be higher in patients using deferasirox compared to controls. Urinary β2-microglobulin levels significantly increased in patients who were receiving high-dose deferasirox compared to those who were receiving a daily dose of 15-20 mg/kg or controls. Subclinical renal injury may be present in TDT patients.

Authors and Affiliations

Agageldi Annayev, Zeynep Karakaş, Serap Karaman, Altan Yalçıner, Alev Yılmaz, Sevinç Emre

Keywords

Thalassemia Tubulopathy Glomerulopathy β2-Microglobulin Cystatin
Download PDF file
  • EP ID EP268180
  • DOI 10.4274/tjh.2017.0266
  • Views 121
  • Downloads 0

How To Cite

Agageldi Annayev, Zeynep Karakaş, Serap Karaman, Altan Yalçıner, Alev Yılmaz, Sevinç Emre (2018). Glomerular and Tubular Functions in Children and Adults with Transfusion-Dependent Thalassemia. Turkish Journal of Hematology, 35(1), 66-70. https://europub.co.uk/articles/-A-268180

Sign In Europub

For faster login or register use your social account.

or
Lost Your Password?
Register