Glutamatergic conception of mood disorders
Journal Title: Psychiatria Polska - Year 2011, Vol 45, Issue 6
Abstract
The neurotransmitter theories of the pathogenesis and treatment of mood disorders presented so far focused mainly on serotonergic and catecholaminergic (noradrenergic and dopaminergic) transmission. In recent decades the attention has been also directed towards a role in the pathogenesis of mood disorders of stress axis dysregulation and of neuroplasticity disturbances, which involve the glutamatergic system. In this paper, a role of glutamatergic neurotransmission in the pathogenesis and treatment of unipolar and bipolar affective illness is presented. In the first part, a role of glutamatergic neurotransmission in the central nervous system is presented, with special focus on glutamatergic receptors. The results of molecular-genetic studies pointing to an association between glutamatergic system genes and a predisposition to unipolar and bipolar affective illness are discussed. In the next part, a summary of neurobiological, including neuroimaging findings as to changes in glutamatergic system in mood disorders is done. Following this, a role of glutamatergic system in the mechanism of action of antidepressant and mood-stabilizing drugs as well as therapeutic activity of drugs modifying glutamatergic system is reviewed. Glutamatergic conception of mood disorders allows for a new look on the pathogenesis and treatment of unipolar and bipolar affective illness.
Authors and Affiliations
Agnieszka Permoda-Osip, Janusz Rybakowski
Keywords
Related Articles
- EP ID EP129752
- DOI -
- Views 98
- Downloads 0
Poziom lęku jako stanu i jako cechy oraz depresji we wczesnym połogu – doniesienie wstępne
Wstęp. Urodzenie dziecka jest zarówno doświadczeniem radosnym, jak i stresującym. To stresujące wydarzenie życiowe powoduje rożne emocje pojawiające się z różnym natężeniem u matek, jednym z nich jest depresja poporodowa...
Difficult road to diagnosing dementia with Lewy bodies (DLB). Case report.
Aim. The main aim of the study was to present the case of a patient with neurological, depressive and psychotic symptoms, most probably connected with progressing dementia with Lewy bodies (DLB). Method. The systematic...
Polish neuropsychiatric environment to sterilization laws in the thirties of the twentieth century
The article describes the considerations that were carried out by Polish psychiatrists and neurologists in the thirties of the twentieth century, due to the sterilization of persons with mental disorders. The paper prese...
Prevalence of depressive disorders in patients with end-stage renal failure
Summary Aim. The depressive symptoms are common in patients with end-stage kidney disease but they are often undiagnosed and can complicate the renal replacement therapy. The aim of this study was to identify signific...
Badania asocjacyjne wybranych polimorfizmów genów DRD2, 5HTT, GRIK3, ADH4 u pacjentów z zespołem zależności alkoholowej
Streszczenie Uzależnienie od alkoholu jest schorzeniem złożonym, uwarunkowanym wieloczynnikowo. Uważa się, że najistotniejszymi czynnikami ryzyka uzależnienia od alkoholu są czynniki genetyczne (40-50% ) i środowiskowe...