Glutathione-S-transferase activity in fractions parasitized by Plasmodium berghei
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 3
Abstract
Glutathione metabolism plays an important role in malaria infected red blood cells and parasite itself. Glutathione-S-Transferase (GST), an antioxidant enzyme plays vital role in protecting the parasite from host induced oxidative damage. During the present study, GST activity was found exhibit concomitant increase with increasing parasitaemia in the erythrocytes and as well as in cell free extract of Plasmodium berghei (NK65), there by suggesting that erythrocytes are under oxidative stress. Results of present study showed 2 fold increase in specific activity of GST at parasitaemia i.e. 20% to 35% which increased to 2.5 fold at 55% parasitaemia. This study suggests the role of GST activity as novel candidate for biochemical markers in malaria.
Authors and Affiliations
Rajesh K. Azad, Nisha Devi, H. S. Banyal
Keywords
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- EP ID EP395135
- DOI 10.9790/3008-1303021418
- Views 79
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