Gold nanoparticles from magnetite for the detection of amyloid proteins in neurodegenerative diseases
Journal Title: One Health & Risk Management - Year 2022, Vol 3, Issue 1
Abstract
Introduction. Currently, neurodegenerative diseases (ND) are the fourth leading cause of death worldwide that pose a great challenge in the development of tools for early diagnosis. Thus, advances in science seek sensitive and selective detection systems and this manuscript will highlight the importance of nanotechnology. Material and methods. A literature review was conducted on the representative findings of NPs technologies in neurodegenerative diseases. Articles written in both English and Spanish were included. References between 2015-2021 were also taken into account. Results. One of the most representative techniques, AuNP was specifically implemented, together with a magnetic center composed of magnetite, which has as a specific ligand with a C-terminal cysteine domain present in the B-amyloid protein, which adhere directly to the surface of the NPs, characterizing the anomalous protein. Subsequently, by means of nanosensors capable of detecting and measuring different concentrations, these pathologies are identified at an early stage. Conclusions. Today, along with the advent of biotechnology, it has been possible to design techniques with NPs that allow the identification of specific mutations and provide diagnosis in individuals. In the investigative models of AuNP, it is possible to infer that the capabilities that make them representative focus on their magnetism and biofunctionality, by specifically binding to amyloid peptides and other ligands present in the protein, which are the major components of amyloid plaques used in these studies.
Authors and Affiliations
Alejandro ORTIZ, Zeyris HERRERA, Johanna MOSCOSO
Keywords
Related Articles
- EP ID EP698659
- DOI 10.38045/ohrm.2022.1.02
- Views 85
- Downloads 0
Current issues related to access and use of information on ex situ conservation of plant genetic resources in the Republic of Moldova
Introduction. The rapid development of information technologies has provided challenges and opportunities for effective documentation of plant genetic resources (PGR). Access to information on PGR is essential for their...
Dietary improvement of the iron statute of the rats with experimental anemia
Introduction. One of the major problems characterizing the nutritional status is the iron deficiency, which leads to decreased immunity, increased incidence of infectious diseases and anemia. Obviously, only well-thought...
Rabies eradication measures in wildlife in the Republic of Moldova
Introduction. Rabies is one of the most dangerous zoonoses in the world with a lethality rate of around 100% of infected animals. The main factor in rabies’ control is the prophylactic immunization of domestic and wild c...
Evaluation of the viability of yeast strains after 15 years of conservation
Introduction. The sustainable and efficient storage of microorganisms in collections depends on the correct selection of the conservation method, parameters and protection media. Material and methods. The viability an...
Vaccines: past, present and future
Introduction. Vaccination is now entering the third century of its practice and it is the most important medical intervention that has ever been implemented. Due to vaccines, the incidence of infectious diseases, which...