GONADAL FUNCTION IN SUBCLINICAL HYPOTHYROIDISM
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2019, Vol 6, Issue 33
Abstract
BACKGROUND We wanted to assess the basal gonadotropin and estradiol levels in women of reproductive age group with subclinical hypothyroidism and evaluate the response of pituitary ovarian axis to leuprolide. METHODS Both in cases and controls, we measured basal follicular stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2) on 3rd or 4th day of menstrual cycle. Leuprolide subcutaneous injection 20 mcg/Kg was given on the same day. 1 hour after injection, stimulated LH levels and E2 measured after 24 hours. Basal values and leuprolide stimulated values were compared between cases and controls. RESULTS Mean basal E2 was 44.16 vs. 55.37 in cases and controls respectively. Mean basal LH in cases was 6.06 ± 2.01 m IU/L vs. 6.63 ± 2.38 m IU/L in controls with a significant p value of 0.01 (p <0.05). Mean basal FSH is 8.39 ± 3.26 mIU/Lvs 7.76 ± 2.90 m IU/L in cases and controls respectively with no significant difference. Mean Peak LH in cases was 20.37 ± 10.32 m IU/ml and in controls it was 20.80 ± 8.67 mIU/ml after leuprolide stimulation. Mean peak E2 in cases and controls was 56.12 and 65.54 pg/ml respectively with no significant difference. CONCLUSIONS Basal LH was lower in cases than controls which is statistically significant. After stimulation with leuprolide, there was no significant difference in LH and E2 levels between cases and controls. It can be concluded that in mild thyroidal failure, the response of pituitary gonadotrophs to leuprolide is normal.
Authors and Affiliations
Annamaneni Geeta Priyadarsini, Lingudu Brahmanandam, Bongi Vivekanand, Ayyagari Mythili, Kandregula Appala Venkata Subrahmanyam
Keywords
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- EP ID EP670449
- DOI 10.18410/jebmh/2019/451
- Views 97
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