Gonadotropin Releasing Hormone Agonists versus Antagonists in Women with Polycystic Ovary Disease Undergoing Intracytoplasmic Sperm Injection
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 11
Abstract
ABSTRACT Introduction: Polycystic ovary syndrome (PCOS) is one of the most important endocrine disorders that cause infertility in young women. Recent meta-analyses have reported that treatment success with GnRH antagonists and GnRH agonists was similar. But no studies are available to determine which protocol is the best in the PCOS patient group. Aim: To compare the Intracytoplasmic Sperm Injection (ICSI) outcome of Gonadotropin Releasing Hormone Agonists (GnRHa) to antagonists (GnRHant) in women with polycystic ovary disease. Materials and Methods: In this retrospective cohort study; out of 3000 patients, 144 women were enrolled who met the inclusion criteria for polycystic ovary disease, according to the Rotterdam criteria at the In-Vitro Fertilization Unit. Cases with GnRHa used for controlled ovarian hyperstimulation (n=95) were compared to cases with GnRHant use (n=49). All analyses were performed using the Statistical Package for Social Sciences software, version 15.0 for Windows. The variables were compared to Pearson Chi-Square and Fisher’s-Exact Tests in 2×2 eyes. Normally distributed (parametric) variables were evaluated between groups, whereas Independent groups were compared using t-test. Results: The mean age, infertility period, FSH level, body mass index and the mean number of embryos transferred were similar in both groups (p>0.05). The average dose of FSH was significantly lower in Group 2 (1765±624 IU) compared to Group 1 (2535±838 IU, p<0.001). The rate of cycle cancellation due to ovarian hyperstimulation risk was 6.4% in group 2, which was similar to the 15.2% in group 1 (p=0.13). The cleavage rate (Group 2; 49.1±22.2%, Group 1; 64.2±24.4%, p=0.001), fertilization rate (Group 2; 48.7±21.5%, Group 1; 63.2±21.5%, p=0.001) and the mean number of good quality embryos transferred (Group 2; 2.5±0.2, Group 1; 2.9±0.8, p=0.02) was significantly lower in group 2 compared to group 1. The clinical pregnancy rate was 30% in group 2 compared to 34.1% in group 1 (p=0.6). The live birth rate was 22.5% in group 2 and 25% in group 1 (p=0.7). Conclusion: Similar clinical pregnancy outcomes can be achieved in GnRH antagonist cycles using lower gonadotropin doses compared to GnRH agonist cycles.
Authors and Affiliations
Onder Sakin, Bulent Kars, Kenan Sofuoglu, Eray Caliskan, Deniz Can Oztekin, Tansel Cetinkaya
Keywords
Related Articles
- EP ID EP526045
- DOI 10.7860/JCDR/2018/37230.12193
- Views 69
- Downloads 0
Students’ Perception and Attitude on Methods of Anatomy Teaching in a Medical College of West Bengal, India
Introduction: Incorporating newer teaching aids over traditional one in Anatomy has been challenging both for the teachers and the learners. Different educational strategies are being used for teaching of Anatomy. Aim: T...
Role of Neck Dissection in Clinical T3 N0 M0 Lesion of Oral Cavity: Changing Trend
Introduction: Neck dissection is an important part in the management of head and neck malignancies especially in terms of control of nodal metastasis. The study is focused on evaluating the profile of lymph nodes in T3 N...
Comparative Efficiency of Muscle Energy Technique and Static Stretching in Enhancing Triceps Surae Flexibility
ABSTRACT Introduction: Flexibility is termed as resilience and painless extensibility of a joint. The reduced flexibility will lead to decreased performance and results in abnormal coordination of movements. To prevent s...
Maintaining ‘V-Contour’ of the Neck after Surgery for Neglected Congenital Muscular Torticollis in an Adult (A New Technique)
ABSTRACT In Congenital Muscular Torticollis (CMT), also called twisted neck or wryneck, an individual holds his or her head tilted to one side. There is a little consensus on the treatment approach of neglected CMT after...
CAD/CAM Prosthetic Options in Rehabilitation of Compromised Ridges with Implants: A Scoping Review
ABSTRACT Introduction: Ridges compromised by tumour resection, trauma and severe atrophy are clinically challenging in prosthetic rehabilitation, predominantly owing to increased crown height space that acts as a stress...