Gouania Longipetala Aqueous Extract Exhibits Antiestrogen
Journal Title: International Journal of Trend in Scientific Research and Development - Year 2021, Vol 5, Issue 5
Abstract
Previous studies showed that G. longipetala aqueous extract GLAE induced estrogenic properties in ovariectomized Ovx rats. The present study aimed to assess antiestrogenic activities and signaling pathways of GLAE. For that, two pharmacological tests were used to evaluate GLAE effects in ovariectomized rats treated with estradiol valerate E2V and a pure antiestrogen ICI 182.780 . Animals were either sham operated or Ovx. 3 day uterotrophic assay was carried out in Ovx adult Wistar rats and GLAE effects were evaluated on the genital tract and mammary gland. Results showed that GLAE reduced significantly vaginotrophic and mammotrophic effects of estradiol valerate. Indeed, GLAE reduced by 68.72 and 62.66 respectively for 45 and 180 mg kg the vaginal epithelial height of E2V Ovx rats. Besides, ICI 182.780 cancelled estrogenic activities of GLAE in both genital tract and mammary gland. Overall, Gouania longipetala aqueous extract activates estrogen receptors to induce estrogen activities and exhibit antiestrogenic properties. Mengue Ngadena Yolande Sandrine | Dzeufiet Djomeni Paul Désiré "Gouania Longipetala Aqueous Extract Exhibits Antiestrogen Activities and Activate Estrogen Receptors in Ovariectomized Wistar Rats" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd43840.pdf Paper URL: https://www.ijtsrd.com/humanities-and-the-arts/psychology/43840/gouania-longipetala-aqueous-extract-exhibits-antiestrogen-activities-and-activate-estrogen-receptors-in-ovariectomized-wistar-rats/mengue-ngadena-yolande-sandrine
Authors and Affiliations
Mengue Ngadena Yolande Sandrine | Dzeufiet Djomeni Paul Désiré
Keywords
Related Articles
- EP ID EP699603
- DOI -
- Views 77
- Downloads 0
A Heart Disease Prediction Model using Logistic Regression
The early prognosis of cardiovascular diseases can aid in making decisions to lifestyle changes in high risk patients and in turn reduce their complications. Research has attempted to pinpoint the most influential factor...
A Review on use of Bituminous Pavementwastes in Cement Concrete
In general, aggregate make up 60 75 of concrete volume, so their selection is important, also they control concrete properties. Aggregate provide strength and wear resistance in these applications. Hence, the selection a...
Risk in Internet Banking: A Theoretical Approach
Internet banking enables customers to do basic banking functions through online. It helps the customer to save time and effort. Introduction of technology brought a new face for banking industry that gives everything by...
Regular Left Derivations on P Semisimple Bcik Algebras
In the present paper, we introduced the notion of left derivation of a BCIK – algebra and investigate some related properties. Using the idea of regular left derivation of a BCIK algebra and investigate p semi simple BCI...
Attitudinal Change towards Technical and Vocational System of Education The Way Forward to Educational Development
The research was conducted to ascertain level of awareness and attitude of parents, students and the public towards technical and vocational system of education. A sample of 400 students from various secondary schools, 4...