Granulocyte colony-stimulating factor potential use in the treatment of children with cerebral palsy
Journal Title: Progress in Health Sciences - Year 2017, Vol 7, Issue 1
Abstract
Granulocyte colony-stimulating factor (G-CSF) is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the blood. Recent studies demonstrated the presence of CSF-receptor (G-CSFR) system in the brain and spinal cord, and their roles in neuroprotection and neural tissue repair, as well as improvement in functional recovery. G-CSF exerts neuroprotective actions through the inhibition of apoptosis and inflammation, and the stimulation of neurogenesis. This review highlights recent studies on the potential use of G-CSF in cerebral palsy.
Authors and Affiliations
G. Paszko-Patej, D. Sienkiewicz, B. Okurowska-Zawada, W. Kułak
Keywords
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- EP ID EP193708
- DOI 10.5604/01.3001.0010.1882
- Views 74
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