Granulocyte-Macrophage Colony-Stimulating Factor-Driven Microglia Contribute To Initiation or Sustaining of Experimental Autoimmune Encephalomyelitis
Journal Title: Journal of Neurological Sciences-Turkish - Year 2006, Vol 23, Issue 3
Abstract
Although not well understood, the elimination and expansion of T cells in the central nervous system (CNS) of experimental autoimmune encephalomyelitis (EAE) is governed by a complex interplay between infiltrated immune cells and resident glial cells. The hematopoietic growth factor, granulocyte macrophage colony-stimulating factor (GM-CSF), is considered to play a central role in maintaining chronic inflammation. Here, we used primary cultured microglia as in vitro experiment and EAE model as in vivo experiment to examine the role of GM-CSF in regulating dendritic-like microglia and in initiating/sustaining CNS inflammation. GM-CSF can promote the generation and maturation of dendritic-like microglia which stimulate the expansion of MBP-reactive T cells. IFN-γ production by T cells was dramatically increased following priming by GM-CSF-treated microglia. No difference in IL-10 secretion by T cells triggered by GM-CSF-treated microglia was observed compared to naive microglia. In vivo experiments, the administration of GM-CSF accelerated the onset and delayed the recovery of EAE, accompanied by increased macrophage and T cell infiltrates in spinal cords. These results hold implications for the pathogenesis of inflammatory and demyelinating disease, providing a new putative therapeutic target in neuroinflammation within the CNS.
Authors and Affiliations
Baoguo XIAO, Wenhua ZHU, Chuanzhen LU
Keywords
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