Granulomatosis with Angitis of Lung treated with Steroids and Rituximab– Case Report and Review of Literature
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 12
Abstract
Granulomatosis with angitis, formerly termed Wegener’s granulomatosis (WG) is an uncommon autoimmune disease with multi‑system involvement, the pathological hallmark of which is necrotizing granulomas with vasculitis. Although it commonly limits itself to involvement of the upper and lower respiratory tracts or kidneys, it may potentially involve any organ. We present the case of a young lady who presented with persistent fever lasting 2 months and right upper lobe consolidation, with laboratory evidence of glomerulonephritis. Serological tests revealed high titres of antibody to proteinase 3 (antineutrophil cytoplasmic antibody – cytoplasmic type- ANCA). A lung biopsy from the left upper lobe revealed necrotizing granulomas with vasculitis, thus clinching the diagnosis. Remission was achieved with a combination of prednisolone with rituximab, complete remission being evidenced as early as 3 weeks of therapy initiation. Steroids were gradually tapered in the maintenance phase and she remains under close follow up for any features of relapse.
Authors and Affiliations
Dr Rajesh V
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