Granulomatosis with Polyangiitis Presenting as a Diagnostic Challenge: A Report of two Cases with Literature Review
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 4
Abstract
ABSTRACT Vasculitis is defined as a clinicopathological entity characterised by inflammation and destruction of the wall of the blood vessel. Granulomatosis with Polyangiitis (GPA), earlier commonly known as Wegener Granulomatosis (WG) is a primary vasculitic pathology, which is a systemic disease with myriads of clinical presentations. It is an uncommon disease presenting with the triad of involvement of upper and lower respiratory tracts along with renal involvement in the form of glomerulonephritis. However, isolated organ involvement as a first clinical presentation without a chronic course of the disease culminating into a diagnosis of GPA is very uncommon and only isolated case reports are available in literature. Here, we describe two case reports of GPA, one of a young girl who presented with chest pain and suddenly developed necrotising scleritis with loss of vision and the second a middle aged female who presented with sudden onset breathlessness without haemoptysis and deranged Kidney Function Test (KFT) which diagnosed it as Pulmonary Renal Syndrome (PRS) {Diffuse Alveolar Haemorrhage (DAH)}. In both the cases, a strong clinical suspicion of vasculitis led to the diagnosis of GPA. These two case reports highlight the importance of timely intervention which resulted in a fruitful outcome for both the patients.
Authors and Affiliations
Jahnvi Dhar, Alpana Meena, Mradul Kumar Daga, Sunita Aggarwal
Evaluation of the Vertical Bone Height of the Palate using CBCT for Placing Micro Implants- A Pilot Study
ABSTRACT Introduction: Determining an ideal anatomical location for mini-implant placement is very crucial for successful use of mini-implants in an orthodontic setup. Some of the factors that should be considered while...
A Rare Case of Marcus Gunn Jaw Winking Phenomenon in a Community Health Setting
Images in Medicine
Variation of Platelet Indices among Patients with Diabetes Mellitus Attending Tertiary Care Hospital
ABSTRACT Introduction: Diabetes Mellitus (DM) is a pandemic health problem. It is considered as a prothrombotic state with enhanced platelet activity. The platelet activation may alter platelet morphology and function wh...
An Insight for the Future Development of Diagnostic Tool by Exploiting Novel Leishmania Donovani Recombinant Hypothetical Protein
ABSTRACT Introduction: Assenting diagnosis of Visceral Leishmaniasis (VL) relies on the detection of Leishmania donovani (L. donovani) in splenic and bone marrow specimens obtained by invasive techniques. Thus, the devel...
Melanoacanthoma of Pinna-Treated with Skin Grafting: A Case Report
ABSTRACT Melanoacanthoma is a very rare cutaneous lesion and it is considered to be a benign neoplasm, which is composed of large dendritic melanocytes and epidermal keratinocytes. Very few case reports of melanoacanthom...