Granulomatous Inflammation: A Comparative Study Using Special Stains on FNAC Smears
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 5
Abstract
Background: Tuberculosis is the most common infectious disease in the developing countries. Inspite of newer modalities for diagnosis and treatment million of people are still suffering and dying from this disease. Many diagnostic tests are devised for its detection including FNAC. This study was designed to discuss the role of Fine Needle Aspiration Cytology using special stains in classifying and diagnosing the cause of granulomatous inflammation in patients diagnosed to have granulomatous inflammation on FNAC. Materials and Methods: A descriptive cross-sectional survey was done on 200 cases of granulomatous inflammation consistent with tuberculosis diagnosed on fine needle aspiration cytology at the Department of Pathology, of Cure Surgical Hospital & Research Center, Solan, H.P, India. All FNAC aspirates showing granulomatous inflammation on light microscopy with Hematoxylin & Eosin staining were subjected to special stains, like ZN, GMS, and PAS. Cases positive for AFB on ZN stain and fungus on GMS/PAS were noted down along with their frequency and percentages. Results: One hundred and four cases (52%) of AFB positive smears were reported in granulomatous inflammation while only 4% cases of fungus were reported down. Cervical lymph nodes were the most commonly involved site (81%), and females were affected more (55%) than males. Most cases of AFBpositive smears were associated with caseation necrosis (96%). Conclusion: Special stains should be done on all granulomatous inflammation cases seen on FNAC for confirmation of TB and ruling out other infectious causes.
Authors and Affiliations
Sharma S
Keywords
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