GREEN SYNTHESIS OF N’-SUBSTITUTED-N”-[4-HYDROXY-3- (1H-INDOL-2-YL) PHENYLDICARBONODITHIOIMIDEDIAMIDE
Journal Title: Indo American Journal of Pharmaceutical Sciences - Year 2018, Vol 5, Issue 4
Abstract
In this work we synthesized a novel series of N’-substituted-N”-[4-hydroxy-3-(1H-indol-2-yl) phenyldicarbonodithioimidediamide by green synthesis parameters from N’-[4-hydroxy-3-(1H-indol-2-yl) phenyl] thiourea and substituted thioformamide. Previously such types of reactions were carried out in acetone medium but we developed new reaction condition in which percentage of acetone was reduced. During synthesis we carried out these reactions in various compositions of ethanol-acetone medium. This method has broad applications due to its efficiency for accelerating a course of organic reactions and increases yields, higher selectivity and lower quantities of byproducts. This method has consequently easier work-up and products obtained are in comparatively pure form. In 70% ethanol-acetone medium we got maximum yields. Justification and confirmations of structure of synthesized compounds were carried by usual elemental analysis, chemical characteristics and spectral studies. Keywords: N’-Substituted-N”-[4-hydroxy-3-(1H-indol-2-yl) phenyldicarbonodithioimide diamide, thioformamide
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RP-HPLC PDA METHOD FOR ESTIMATION OF PRULIFLOXACIN IN BULK AND PHARMACEUTICAL DOSAGE FORM
A rapid and precise Reverse Phase High Performance Liquid Chromatographic method has been developed for the validated of Prulifloxacin in its pure form as well as in tablet dosage form. Chromatography was carried out on...
HEMATOLOGICAL STUDIES AMONG GURHAKU SMOKERS IN SELECTED AREAS OF BALOCHISTAN
Gurhaku, is one of the newly emerging smoking materials, prepared by mixing tobacco dust and molasses smoked in hookah. Tobacco smoking causes human health problems and has got a close association with the environmental...
EFFECTIVENESS OF EDUCATIONAL AND AWARENESS SESSIONS ALONG WITH APPROPRIATE STRATEGIES IN ORDER TO DISCOURAGE AN ELECTIVE CAESARIAN SECTION (CS) IN PRIMIPARAS WOMEN TO REDUCE ASSOCIATED COMPLICATION IN MOTHERS AND NEWBORNS
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