GROWING CONCERN OF METHICILLIN RESISTANCE Staphylococcus aureus FROM A TERTIARY CARE HOSPITAL, INDIA
Journal Title: International Journal of Microbiology Research - Year 2016, Vol 8, Issue 7
Abstract
Background: Staphylococcus aureus (S. aureus) remains, to date, one of the major causes of both health-care associated (HA) and community-associated (CA) infections. S. aureus causes a variety of infections, ranging from skin and soft tissue infections [SSTI] to life threatening endocarditis. The present study was conducted to characterize Methicillin resistant S. aureus (MRSA) infections with reference to associated risk factors, clinical syndrome and its development of antimicrobial resistance. Methods: 400MRSA were isolated by standard conventional methods from various clinical samples received in the department of microbiology. Antimicrobial susceptibility was determined by CLSI guidelines. Inducible clindamycin were detected by as per CLSI guidelines by D-zone test. Demographic and clinical history was collected from medical record. Results: Total of 400 MRSA were collected from various clinical samples received from various wards and intensive care units (ICUs). 107 (26.75%) MRSA were from blood stream infections (BSIs) and endocarditis, 81(20.25%) were from osteomyelitis and septic arthritis, 97(24.25%) were from skin and soft tissue infections, 62(15.5%) were from pneumonia, 45(11.25%) were from urinary tract infection (UTI). Of the total 400 MRSA strains; 183(45.75%) strains were isolated from pediatric and neonatal age group. 41 % MRSA strains were isolated from various intensive care Unit. 35.75% strains were determined as a inducible clindamycin phenotype while all MRSA strains were susceptible for vancomycin and tigecycline. 99.5% strains were susceptible for linezolid. 75.25% and 42.75% MRSA strains were defined as CA-MRSA and HA-MRSA according to CDC epidemiologic definitions by clinical criteria; Conclusion: Local surveillance data to identify prevalent pathogens, detect bacterial resistance and to identify disseminated strains is decisive to the selection of best possible treatment regimens.
Authors and Affiliations
M. T. UJAGARE, R. N. MISRA, N. R. GANDHAM, S. V. JADHAV, A. D. DESHMUKH, K. M. ANGADI, C. R. VYAWAHARE, N. G. GUPTA
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