GROWTH CHARACTERIZATION OF CALCIUM HYDROGEN PHOSPHATE DIHYDRATE CRYSTALS INFLUENCED BY COSTUS IGNEUS AQUEOUS EXTRACT
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2017, Vol 9, Issue 5
Abstract
Objective: To investigate the inhibitory effect of aqueous extract of leaves, stems and rhizome of Costus igneus on the growth of calcium hydrogen phosphate dihydrate (CHPD) crystals.Methods: Calcium hydrogen phosphate dihydrate (CHPD) crystals were grown by the single diffusion gel growth technique and the inhibitory effect of aqueous extracts of leaves, stems and rhizome of Costus igneus on the growth of CHPD crystals has been studied. The grown crystals were characterised by Fourier Transform Infrared Spectroscopy (FTIR), Powder X-Ray diffraction (XRD) for further confirmations.Results: With an increase in the concentration of aqueous extract of Costus igneus, the weight of the formed crystals were gradually reduced from 2.03 g to 0.06 g (leaves), 0.05 g (rhizome), 0.03 g (stem) for the CHPD crystals, respectively. The crystals harvested from the CHPD were characterised by Fourier Transform Infrared Spectroscopy (FTIR) to confirm the functional groups, and Powder X-Ray Diffraction technique (XRD) analyses to confirm the crystalline phases of the CHPD and hydroxyapatite (HAP) crystals. Results obtained indicated that Costus igneus (leaves, stems and rhizome) has the potential to inhibit the formation of calcium hydrogen phosphate dihydrate crystals.Conclusion: This study confirms that using an aqueous extract of stem and rhizome of Costus igneus can promote the formation of hydroxyapatite (HAP) crystals and reduce the nucleation rate of CHPD crystals, a major component of calcium urinary stone.
Authors and Affiliations
Thanikasalam Yuvarani, Kesavan Manjula, Perumal Ananda Gopu
Keywords
Related Articles
- EP ID EP575651
- DOI 10.22159/ijpps.2017v9i5.16838
- Views 107
- Downloads 0
PARENTAL KNOWLEDGE, ATTITUDES AND PRACTICES (KAPs) ON THE USE OF ANTIBIOTICS IN CHILDREN FOR UPPER RESPIRATORY TRACT INFECTIONS (URTIs)
Objective: This study aimed to assess the knowledge, attitudes and practices (KAPs) of parents on the use of antibiotics among children for upper respiratory tract infections (URTIs).Methods: This cross-sectional study w...
XANTHINE OXIDASE INHIBITORY EFFECTS OF PISTACIA LENTISCUS L. LEAVES EXTRACTS
Objective: The aim of this study is to evaluate the inhibition of the xanthine oxydase (XO) by the crude extract of Pistacia lentiscus L. leaves and their subsequent fractions (chloroformic, ethyl acetate, butanolic and...
FORMULATION AND EVALUATION OF OXICONAZOLE MUCOADHESIVE NANOEMULSION BASED GEL FOR TREATMENT OF FUNGAL VAGINAL INFECTION
Objective: The aim of the present study was to formulate and evaluate nanoemulsion-based gel of oxiconazole nitrate (OXZ) for the treatment of vaginal infection.Methods: The solubility of Oxiconazole nitrate in various o...
BRAZILEIN INCREASES THE SENSITIVITY OF DOXORUBICIN ON MCF-7 RESISTANT DOXORUBICIN (MCF-7/DOX) CELLS THROUGH INHIBITION OF HER-2 ACTIVATION
Objective: Brazilein is a compound obtained in a large amount from the dried heartwood of Secang (Caesalpinia sappan L.). Brazilein has strong cytotoxic effect in several cancer cell lines. This study was designed to eva...
DEVELOPMENT AND EVALUATION OF IN SITU NASAL MUCOADHESIVE GEL OF METOPROLOL SUCCINATE BY USING 32 FULL FACTORIAL DESIGN
Objective: To develop and evaluate in situ nasal mucoadhesive gel of metoprolol succinate.Methods: In situ nasal mucoadhesive gel was formulated by cold method using Carbopol 940 as a pH sensitive polymer, xanthan gum as...