GROWTH CHARACTERIZATION OF CALCIUM HYDROGEN PHOSPHATE DIHYDRATE CRYSTALS INFLUENCED BY COSTUS IGNEUS AQUEOUS EXTRACT
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2017, Vol 9, Issue 5
Abstract
Objective: To investigate the inhibitory effect of aqueous extract of leaves, stems and rhizome of Costus igneus on the growth of calcium hydrogen phosphate dihydrate (CHPD) crystals.Methods: Calcium hydrogen phosphate dihydrate (CHPD) crystals were grown by the single diffusion gel growth technique and the inhibitory effect of aqueous extracts of leaves, stems and rhizome of Costus igneus on the growth of CHPD crystals has been studied. The grown crystals were characterised by Fourier Transform Infrared Spectroscopy (FTIR), Powder X-Ray diffraction (XRD) for further confirmations.Results: With an increase in the concentration of aqueous extract of Costus igneus, the weight of the formed crystals were gradually reduced from 2.03 g to 0.06 g (leaves), 0.05 g (rhizome), 0.03 g (stem) for the CHPD crystals, respectively. The crystals harvested from the CHPD were characterised by Fourier Transform Infrared Spectroscopy (FTIR) to confirm the functional groups, and Powder X-Ray Diffraction technique (XRD) analyses to confirm the crystalline phases of the CHPD and hydroxyapatite (HAP) crystals. Results obtained indicated that Costus igneus (leaves, stems and rhizome) has the potential to inhibit the formation of calcium hydrogen phosphate dihydrate crystals.Conclusion: This study confirms that using an aqueous extract of stem and rhizome of Costus igneus can promote the formation of hydroxyapatite (HAP) crystals and reduce the nucleation rate of CHPD crystals, a major component of calcium urinary stone.
Authors and Affiliations
Thanikasalam Yuvarani, Kesavan Manjula, Perumal Ananda Gopu
DEVELOPMENT OF AN INDICATOR BASED TOOL FOR THE ASSESSMENT OF MEDICINES SELECTION PRACTICES IN VARIOUS PUBLIC SECTOR HOSPITALS
Objective: To develop and validate an indicator based assessment tool for carrying out an in-depth assessment of drug selection practices prevalent at various public health facilities.Methods: The study was designed acro...
IN SILICO STUDY FOR IDENTIFICATION OF DRUG LIKE INHIBITOR FROM NATURAL COMPOUNDS AGAINST INHA REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS
Objective: Natural products have played an important role for developing new drugs and becoming popular due to toxicity and side effects of allopathic medicine. The main objective of this research work is to find drug-li...
ANTIOXIDANT AND HYPOGLYCEMIC EFFECTS OF CURCUMIN PYRAZOLE DERIVATIVES
Objective: To investigate the antioxidant properties of curcumin pyrazole derivatives using different in-vitro models and hypoglycemic potential by gluconeogenesis studies.Methods: Antioxidant ability of curcumin pyrazol...
EFFECT OF SELECTED HEAVY METALS (LEAD AND ZINC) ON SEEDLING GROWTH OF SOYBEAN GLYCINE MAX (L.) MERR
Objective: This study was designed to evaluate the effects of different concentrations of both zinc (250, 500, 750, 1000 and 1250 mg/kg) and lead (200, 400, 600, 800, 1000 mg/kg) as zinc sulphate and lead acetate respect...
ANTIMICROBIAL AND CYTOTOXIC ACTIVITIES OF BIOACTIVE COMPOUNDS PRODUCED BY STREPTOMYCES SP. KB1
Objective: To investigate the antimicrobial and cytotoxic activities of bioactive compounds produced by Streptomyces sp. KB1 isolated from the air sample at Ao-nang, Krabi province, Thailand.Methods: Streptomyces sp. KB1...