Growth differentiation factor 15 and arterial remodeling in adult patients after succesful repair of aortic coarctation (RCD code: IV-5.A.1)
Journal Title: Journal of Rare Cardiovascular Diseases - Year 2013, Vol 1, Issue 2
Abstract
Background: Coarctation of aorta (CoAo) is a congenital heart anomaly associated with high cardiovascular morbidity and mortality attributable to vascular remodeling in adult survivors following surgical management of aortic stenosis. This study sought to adjudicate the significance of novel stress-responsive biomarker, growth differentiation factor 15 (GDF-15), as an indicator of vascular remodeling and its correlation with numerous laboratory and vascular parameters in patients after successful CoAo repair.Methods and results: This research is a case-control study comprising 33 consecutive patients (19 men, 57.58%; mean age 33.9 ±9.3 years; mean age at surgery: 9.1 ±7 years; mean follow-up duration 24.8 ±6.8 years) admitted to outpatient clinic for routine follow-up after repair of CoAo (mainly Dacron patch technique) and matched with 20 healthy controls (10 men, 50%; mean age 34.8 ±9.9 years). Laboratory (GDF-15, high-sensitivity C-reactive protein) and vascular parameters (intima-media thickness, flow- and nitrate-mediated dilation, pulse-wave velocity, central arterial pressure) were assessed. Significant aortic residual gradient was present in 24 (72.7%). The circulating GDF-15 level was lower in CoAo survivors than in control group (539.56 vs. 744.98 pg/ml respectively; p < 0.001). GDF-15 concentration <550 pg/ml successfully differentiated patients after CoA repair (odds ratio [OR] = 9.2; 95%CI: 2.45–34.56, p = 0.0005). There was no difference in GDF-15 level depending on the presence of significant residual gradient (p = 0.19). No significant correlation between GDF-15 and other variables was observed. Conclusions: Low concentration of GDF-15 is characteristic of asymptomatic patients following CoAo repair, however, its clinical significance and relationship with vascular remodeling substantiates further investigation. JRCD2013; 1 (2): 5–12Key words: coarctation of aorta, GDF-15, growth differentiation factor 15, vascular remodeling
Authors and Affiliations
Katarzyna Mizia-Stec, Maciej Wybraniec, Olga Trojnarska, Jerzy Chudek
Keywords
Related Articles
- EP ID EP245377
- DOI 10.20418/jrcd.vol1no2.77
- Views 94
- Downloads 0
Ebstein Anomaly
Ebstein anomaly (EA) is a rare congenital malformation of the heart that is characterized by apical displacement of the septal and posterior tricuspid valve leaflets, with atrialization of the right ventricle and variabl...
Partial anomalous pulmonary venous connection (RCD code: II-3C.0)
A 48-year-old woman was admitted to our institution with a year’s history of uncharacteristic chest pain episodes and decrease in exercise tolerance. A CT lung scan performed nine months earlier revealed an anomalous vei...
4th Symposium on Rare Cardiovascular Diseases – ESC Barcelona 2014
Raport from the Satellite Symposium on Rare Cardiovascular Diseases.
Spontaneous implantation of a left atrial myxoma into the left ventricle (RCD code: VI‑1A.1)
Myxomas are one of the most common cardiac tumors. In 70–80% of cases they are located in the left atrium, 10–20% in the right atrium and in less than 10% in ventricles. We report a case of a 60-year-old patient after my...
Accidentally discovered non‑compaction cardiomyopathy in patient with initial diagnosis of acute coronary syndrome (RCD code: III-5A)
Isolated non‑compaction cardiomyopathy is a rare congenital developmental disorder, which belongs to the group of unclassified cardiomyopathies by the ESC Position Statement. Typical echocardiographic findings include mu...