Growth Factor Receptor Tyrosine Kinase Inhibitors in Non-small cell lung cancer
Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2015, Vol 3, Issue 2
Abstract
Aberrant increased expression and activation of receptor tyrosine kinases occur frequently in human carcinomas. Several small molecules targeting receptor tyrosine kinases, which have crucial roles in the growth factor signaling that promote tumor progression in various malignancies, including non-small cell lung cancer (NSCLC), are currently in clinical development. Therapeutic strategies include inhibition of growth factor tyrosine kinase function. Drugs of this type include those that target the epidermal growth factor receptor tyrosine kinase, those that target vascular endothelial growth factor receptors tyrosine kinase and those that target anaplastic lymphoma receptor tyrosine kinase. In this review we first discuss the role of receptor tyrosine kinases in human malignancies, and focus on discussing the potential use of epidermal growth factor receptor tyrosine kinase inhibitors and the vascular endothelial growth factor receptors tyrosine kinase inhibitors in NSCLC. In addition, we discuss the contribution of growth factor receptor tyrosine kinase inhibitors to the clinically observed resistance, and toxicity.
Authors and Affiliations
Lawaly Maman Manzo| Department of Biochemistry, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, P. R., China Laboratoire de Biochimie Clinique, Hopital National de Niamey, BP 238 Niamey, Niger, Moudirat Lawaly| Centre National de Traitement du Cancer, BP 238 Niamey, Niger, Lui YU| Department of Biochemistry, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, P. R., China
Keywords
Related Articles
- EP ID EP15338
- DOI -
- Views 338
- Downloads 13
Emulgel: Magnifying the application of topical drug delivery
Topical drug delivery is mostly culled for the local dermatological action, but recently the new technologies are also enhancing its systemic effect. They are generally applied for the purpose as antiseptics, antifungal...
Comparaative study of Lipid profile and level of Antioxidant enzymes in cigarette smokers with non cigaretee smokers
Cigarette smoking is the serious health problems and most important avoidable cause of death in world. Worldwide more than 8 million people currently die each year from smoking half of them before of the age of 60. Eve...
Prescription pattern of NSAIDS and the prevalence of NSAID-induced gastrointestinal risk factors of orthopaedic patients
Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly used medications in the world. NSAID-induced adverse reactions involve upper gastrointestinal (GI) tract complications, which can be...
Evaluation of pharmacological potentials of the ethanolic extract of a mushroom (Ganoderma lucidum) grown in FCT
The aim of this research work is to evaluate the pharmacological potentials of the mushroom Ganoderma lucidium grown in Federal Capital Territory Abuja, Nigeria. Phytochemical, antioxidant and antibacterial properties...
An Overview on Biopesticidal and Virulent nature with Pathogenic aspects of Entomopathogenic fungi on Insects
Entomopathogenic fungi are very heterogeneous group used for management of insect pest. From last 2 decade in the search for new avenues in biological control, the importance of entomopathogens has been highlighted as an...