Guideline for PET/CT Imaging of Neuroendocrine Neoplasms with 68Ga-DOTA-conjugated Somatostatin Receptor Targeting Peptides
Journal Title: Nuclear Medicine Seminars - Year 2020, Vol 6, Issue 3
Abstract
Neuroendocrine tumors (NETs) are one of the rare cancers that have been increasing in recent years. The importance of Ga-68 DOTA-Conjugated Peptides Receptor imaging has been reported in many retrospective and prospective studies in the diagnosis and clinical management of NETs. Three different somatostatin analogues labeled Ga-68 are used in clinical practice. The most commonly used Ga-68 DOTA-Conjugated Peptides are DOTA-D-Phe-Tyr3-octreotide (DOTA-TOC), DOTA-1-NaI (3)- octreotide (DOTA-NOC) and DOTA-D-Phe-Tyr3-octreotate (DOTA-TATE) in rutin. Although all these radiopeptides bind to sst-r 2, each has different affinity profiles for other sst-r subtypes. Performed related studies have shown that the compound with the highest affinity for somatostatin receptor 2 (sst-r 2), which is most frequently expressed in NETs, is DOTA-TATE. Ga-68 DOTA-bound somatostatin receptor (sst-r) PET/CT is used in the preoperative staging of NETs, determination of treatment response, restaging, showing somatostatin receptor uptake before peptide receptor radionuclide treatment. This guideline, mainly for nuclear medicine physicians contains recommendations in terms of procedure, reporting and interpretation in order to standardize Ga-68 DOTA conjugated peptid PET/CT imaging in NETs.
Authors and Affiliations
Nalan Alan Selçuk, Emre Demirci, Levent Kabasakal, Gülin Uçmak, Umut Elboğa, Cüneyt Türkmen, İlknur Ak Sivrikoz
Keywords
Related Articles
- EP ID EP691581
- DOI 10.4274/nts.galenos.2020.0032
- Views 85
- Downloads 0
Radionuclide Methods for Pain Palliation
Bone is a common metastatic site of cancer. Bone metastasis reduces life expectancy and results in serious symptoms and complications such as bone pain, pathological fractures, spinal cord compression, and malignant hype...
Radionuclide Treatment in Pain Palliation
Skeletal system is the most common metastasis site in patients with advanced cancer. Pain is an important health problem in patients with bone metastasis. Bone seeking radionuclides to treat bone pain due to bone metasta...
Early and Late Side Effects and Patient Management in I-131 Treatment
I-131 is the first most experienced theranostic radionuclide that has been used since the early 1940s for the treatment of hyperthyroidism, metastases or ablation of residual thyroid tissue in well-differentiated thyroid...
Standardized Reporting of Myocardial Perfusion SPECT Imaging
Myocardial perfusion single photon emission computerized tomography (MPS) report is the final product of a series of complex procedures, starting with patient preparation and ending with interpretation of the process. Th...
Quality Control of Magistral (or in House or Smallscale) Produced Radiopharmaceuticals
As it is known, magistral radiopharmaceuticals are suitable for only in house use and are prepared, produced and supplied with a medical prescription for a certain patient in good laboratory practice (GLP) standard by a...