GUT MICROBIOTA CHANGE AND TIME OF RESTORE IN INTENSIVE CARE THERAPY: A CASE REPORT
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2016, Vol 5, Issue 1
Abstract
Exposure of gut microbiota to antibiotics can promote antibiotic resistance and development of diseases caused by multi-drug-resistant organisms. Here we present a case of a 54-year-old male patient with a diagnosis of acute cholecystitis with significant biliary duct leakage, admitted to Intensive Care Unit (ICU) due to a septic syndrome after surgery. Fecal microbial population was analyzed by DGGE and Real Time PCR during and after a combined antibiotic therapy and enteral nutritional feeding. Gut microbiota dysbiosis was demonstrated during ICU recovery. After antibiotic therapy discontinuation and the switch to normal diet, microbial gut population gradually increased up to values comparable with those of a healthy subject. Bifidobacterium spp. took longer to re-stabilize, reaching normal value after two weeks. Our case report corroborates the resilient nature of gut microbiota, but points out the long time needed to recover after antibiotic treatment, paving the way to supplementation with key probiotic species.
Authors and Affiliations
Francesca Borgo| Department of Health Sciences, Università degli Studi di Milano, via di Rudinì, 8, Milan, Italy, Elisa Borghi| Department of Health Sciences, Università degli Studi di Milano, via di Rudinì, 8, Milan, Italy, Silvia Marzorati| Intensive Care Unit, San Paolo Hospital, via di Rudinì, 8, Milan, Italy, Gaetano Iapichino| Department Pathophysiology and Transplantation, Università degli Studi di Milano, via F. Sforza, 35, Milan, Italy, Intensive Care Unit, San Paolo Hospital, via di Rudinì, 8, Milan, Italy, Giulia Morace| Department of Health Sciences, Università degli Studi di Milano, via di Rudinì, 8, Milan, Italy, Email: giulia.morace@unimi.it
Keywords
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- EP ID EP11577
- DOI 10.5958/2319-5886.2016.00024.2
- Views 297
- Downloads 10
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