GUT MICROBIOTA CHANGE AND TIME OF RESTORE IN INTENSIVE CARE THERAPY: A CASE REPORT
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2016, Vol 5, Issue 1
Abstract
Exposure of gut microbiota to antibiotics can promote antibiotic resistance and development of diseases caused by multi-drug-resistant organisms. Here we present a case of a 54-year-old male patient with a diagnosis of acute cholecystitis with significant biliary duct leakage, admitted to Intensive Care Unit (ICU) due to a septic syndrome after surgery. Fecal microbial population was analyzed by DGGE and Real Time PCR during and after a combined antibiotic therapy and enteral nutritional feeding. Gut microbiota dysbiosis was demonstrated during ICU recovery. After antibiotic therapy discontinuation and the switch to normal diet, microbial gut population gradually increased up to values comparable with those of a healthy subject. Bifidobacterium spp. took longer to re-stabilize, reaching normal value after two weeks. Our case report corroborates the resilient nature of gut microbiota, but points out the long time needed to recover after antibiotic treatment, paving the way to supplementation with key probiotic species.
Authors and Affiliations
Francesca Borgo| Department of Health Sciences, Università degli Studi di Milano, via di Rudinì, 8, Milan, Italy, Elisa Borghi| Department of Health Sciences, Università degli Studi di Milano, via di Rudinì, 8, Milan, Italy, Silvia Marzorati| Intensive Care Unit, San Paolo Hospital, via di Rudinì, 8, Milan, Italy, Gaetano Iapichino| Department Pathophysiology and Transplantation, Università degli Studi di Milano, via F. Sforza, 35, Milan, Italy, Intensive Care Unit, San Paolo Hospital, via di Rudinì, 8, Milan, Italy, Giulia Morace| Department of Health Sciences, Università degli Studi di Milano, via di Rudinì, 8, Milan, Italy, Email: giulia.morace@unimi.it
Keywords
Related Articles
- EP ID EP11577
- DOI 10.5958/2319-5886.2016.00024.2
- Views 240
- Downloads 10
The Comparison of the effectiveness of Two Education Methods video and lecture on Knowledge, Belief and Practice of Hand Hygiene in Nursing Students: Clinical Trial
Using educational methods among nursing students is very important, as they increase knowledge and affect their attitude and ultimately their performance. The use of an effective training method leads to reform and chan...
The possible role of oxidants and antioxidant imbalance in pathophysiology of Schizophrenia
Background: Employment of low dose combinations of two antihypertensives, with different mode of action has gained acceptance worldwide for the treatment of mild to moderate hypertension. However, most studies in hyperte...
Age related changes in size of thyroid follicle in north Indian population: A histologic study
Due to increasing number of cases of thyroid gland disorders nowadays, there are rising trends of thyroid gland surgeries and interventions which requires comprehensive data regarding the gland. This study was done to f...
Water Fortified With Minerals (Ca, Mg, Fe, Zn)
The many health attributes of functional beverages have resulted in the rapid growing of their market sale. Waterbased beverages fortified with minerals have made a new connection between the medical and food sciences....
Taxonomy level of pediatrics exams and psychometric characteristics of MCQ test in year 2014
Educational assessment not only needs to examine the test items making up the test but also to evaluate the level of learning of test takers. The purpose of this research was to examine the multiple choice items indices...